Glutamate receptor-dependent regulation in hippocampal neurogenesis focused on NMDA receptor

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Glutamate receptors of NMDA and AMPA type control emotional expressions by regulating hippocampal neurogenesis in the dentate gyrus. Blockings of NMDA receptors and activations of Ca2+-permeable AMPA receptors facilitated neurogenesis. Reduced anxiety was observed in GRIA2 disrupted mice, which lack GluA2 subunit of the AMPA receptor, in elevated plus maze task. Blocking of neurogenesis by X-ray irradiation did not increase the degrees of anxiety in these mice.