Glutamate receptor-dependent regulation in hippocampal neurogenesis focused on NMDA receptor

NMDA和AMPA型谷氨酸受体通过调节海马齿状回的神经发生来控制情绪表达。阻断NMDA受体和激活钙离子通透性AMPA受体促进神经发生。在高架加迷宫任务中，观察到缺乏AMPA受体GluA2亚单位的GRIA2干扰小鼠的焦虑程度降低。通过X射线照射阻断神经发生并没有增加这些小鼠的焦虑程度。

Glutamate receptors of NMDA and AMPA type control emotional expressions by regulating hippocampal neurogenesis in the dentate gyrus. Blockings of NMDA receptors and activations of Ca2+-permeable AMPA receptors facilitated neurogenesis. Reduced anxiety was observed in GRIA2 disrupted mice, which lack GluA2 subunit of the AMPA receptor, in elevated plus maze task. Blocking of neurogenesis by X-ray irradiation did not increase the degrees of anxiety in these mice.