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Development and in-vivo application of functional manganese-enhanced MR molecular imaging

Development and in-vivo application of functional manganese-enhanced MR molecular imaging
功能性锰增强磁共振分子成像的开发及体内应用
批准号:
21500419
负责人:
AOKI Ichio
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Molecular mechanism of manganese contrast agent(Mn^<2+>) was investigated, as well as following applications : 1) quantitative evaluation for microencephaly model by neonatal radiation, 2) quantitative observation of Mn accumulation in tumor cells and application for higher Mn-SOD expressed mesothelioma model, 3) development and in-vivo application of monocyte labeling using Mn^<2+>. Positive contrast agent, Mn^<2+>, with high field and quantitative MRI can provide promising in-vivo molecular imaging to assess cellular level alteration or disease non-invasively.
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DOI: 10.1371/journal.pone.0025487
发表时间: 2011
期刊: PloS one
影响因子: 3.7
作者: [Odaka K, Aoki I, Moriya J, Tateno K, Tadokoro H, Kershaw J, Minamino T, Irie T, Fukumura T, Komuro I, Saga T]
通讯作者: Saga T
DOI: --
发表时间: 2010
期刊: Neuroscience
影响因子: 3.3
作者: [Sawada K, Sun XZ, Fukunishi K, Kashima M, Saito S, Sakata-Haga H, Sukamoto T, Aoki I, Fukui Y.]
通讯作者: Fukui Y.
DOI: 10.1016/j.biomaterials.2010.10.050
发表时间: 2011-02-01
期刊: BIOMATERIALS
影响因子: 14
作者: [Kono, Kenji, Nakashima, Seiji, Ishizaka, Yukihito]
通讯作者: Ishizaka, Yukihito
Optimization of Liposomal Theragnosis : Quantitative T_1 Measurement of Drug Distribution and Release in Deep-Seated Tumor Using Multimodal Thermo-Sensitive Polymer-Modified Liposome
脂质体治疗的优化:使用多模式热敏聚合物修饰脂质体定量 T_1 测量深部肿瘤中的药物分布和释放
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kokuryo, Daisuke ; Nakashima, Seiji ; Chuang, Kai-Hsiang ; Kanno, Iwao ; Kono, Kenji ; Aoki, Ichio]
通讯作者: Ichio
34
    Development of Cellular and Molecular Magnetic Resonance Imaging and Application using targeted multimodal probes.
    海外基金