Structural analysis of the ribosome-bound GTPase family

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In translation process, GTP-bound translation factors bind to "GTPase-associated center" in the ribosomal large subunit one by one, and cause GTP hydrolysis. To elucidate its hydrolysis mechanism, the structure determinations of the complex structures of GTP-bound translation factors/GTPase-associated center are necessary. Recently, our research group has detected the direct binding between EF-1α, one of the GTP-bound translation factor, and P1 protein, a component of GTPase-associated center. In this research, we have determined the complex structure of EF-1α and P1 protein by X-ray crystallography in an atomic resolution.