Structural study of the chromosomal crossing-over resolution by the progeroid syndrome helicases

已经对与人类加速衰老疾病相关的蛋白质和在细胞信号通路中起作用的蛋白质进行了结构研究。确定了“Werner综合征WRN解旋酶与双链DNA复合体的RQC结构域”、“Bloom综合征BLM解旋酶的HRDC结构域”以及“异三聚体G蛋白与其特异性抑制剂YM-254890复合体”的三维结构。这些新的结构为生物学和医学领域提供了新的见解。

Structural studies of the proteins that are associated with human accelerated-aging diseases and the proteins that function in the cell signaling pathway, have been performed. Three-dimensional structures of the “RQC domain of Werner syndrome WRN helicase in complex with double-stranded DNA”, “HRDC domain of Bloom syndrome BLM helicase”, and the “heterotrimeric G protein in complex with its specific inhibitor YM-254890” have been determined. These new structures offered insights into the field of biology and medicine.