Structural study of telomere maintenance mechanism of RecQ helicases

RecQ家族的DNA解旋酶WRN （Werner综合征蛋白）和BLM （Bloom综合征蛋白）在保护基因组免受有害变化方面起着关键作用。在这项研究中，我们确定了人类BLM中与磷酸盐离子结合的RecQ c -末端（RQC）结构域的第一个三维结构。我们的研究结果揭示了RecQ解旋酶对重组和修复中间体的独特dna解绕活性(Kim， SY。，北野，K., 2013, Sci。众议员，3,3294 .)。

RecQ family of DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. In this study, we determined the first three-dimensional structure of a RecQ C-terminal (RQC) domain from human BLM bound to a phosphate ion. Our result gave insights into the unique DNA-unwinding activity of RecQ helicases toward recombination and repair intermediates (Kim, SY., Hakoshima, T., and Kitano, K., 2013, Sci. Rep., 3, 3294.).