Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidase
Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidase
批准号:
21780103
负责人:
GOTO Yoshikuni
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Adipocyte-derived leucine amnopeptidase (A-LAP) may play role in the blood pressure regulation. In this study, it is revealed that ER-retained A-LAP is secreted from macrophages in response to activation by treatment with lipopolysaccharide and interferon-γ, and supply of arginine for nitric oxide synthesis from peptide to cells. These results suggest that secretion of A-LAP is important for hypertensive action.
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Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
编码内质网氨肽酶 1 的单核苷酸多态性可通过影响酶的基本酶性质来影响体外抗原肽的生成
DOI:
--
发表时间:
2011
期刊:
Journal of Immunology
影响因子:
4.4
作者:
[Takeshi Ikeda, Kei Motomura, Yuuya Agou, Takenori Ishida, Ryuichi Hirota, Akio Kuroda, Irini Evnouchidou]
通讯作者:
Irini Evnouchidou
マクロファージにおけるカルシウムを介した小胞体アミノペプチダーゼ-1の分泌
巨噬细胞中钙介导的内质网氨肽酶-1 分泌
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[池田丈, 本村圭, 吾郷友哉, 廣田隆一, 黒田章夫, 後藤芳邦]
通讯作者:
後藤芳邦
DOI:
10.1074/jbc.m111.239111
发表时间:
2011-06-17
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Goto, Yoshikuni, Ogawa, Kenji, Tsujimoto, Masafumi]
通讯作者:
Tsujimoto, Masafumi
マクロファージにおける小胞体アミノペプチダーゼ-1の分泌
巨噬细胞内质网氨肽酶-1的分泌
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ito S, Kawamura H, Niwa Y, Nakamichi N, Yamashino T, Mizuno T, 後藤芳邦]
通讯作者:
後藤芳邦
Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q
谷氨酰胺 238 参与人 Laeverin/氨肽酶 Q 的底物特异性
DOI:
--
发表时间:
2011
期刊:
Biological & Pharmaceutical Bulletin
影响因子:
2
作者:
[Takeshi Ikeda, Kei Motomura, Yuuya Agou, Takenori Ishida, Ryuichi Hirota, Akio Kuroda, Yoshikuni Goto]
通讯作者:
Yoshikuni Goto
共 8 条
Dysfunction of ERAP1 induces anxiety disorder via excess serotonin synthesis
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批准号:19K07405
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
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负责人:GOTO Yoshikuni
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依托单位:
Roles of ER aminopeptidase 1 in inflammation of Behcet's disease
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批准号:16K08630
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2016
-
负责人:GOTO Yoshikuni
-
依托单位:
Contribution of ER-aminopeptidase secretion to classical activation of macrophages
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批准号:24790083
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
-
财政年份:2012
-
负责人:GOTO Yoshikuni
-
依托单位:
海外基金