Development of delivery systems of functional food factors by vesiculation and modulation of transepithelial transport

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In this research, we aimed to enhance the absorption of functional food factors, especially flavonoids, by optimization of vasiculation condition of flavonoids and by modulation of transepithelial transport in the intestine. When flavonoids were incorporated to vesicles, flavonoids were stably suspended beyond their saturated concentrations, and quercetin was protected from degradation in aqueous media. Permeated hesperetin across the Caco-2 cell monolayer was significantly increased when hesperetin coexisted with lipid vesicles. Several genes related to intracellular transport were down- or up-regulated by the treatment with dipeptide Trp-Gly in Caco-2 cells, suggesting that these genes possibly become the target for modulation of transepithelial transport by food components.