Relationship between intestinal microbiota and allergy development - Novel target on allergy suppression by food
Relationship between intestinal microbiota and allergy development - Novel target on allergy suppression by food
批准号:
23780149
负责人:
WATANABE Jun
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
The aim of this study was to clarify the relationship between intestinal microbiota and allergy development and the effect of maternal allergen intake during lactating period on immune reactions in offspring. Microbiota was changed in the intestine of DO11.10 mice, when those were sensitized by oral OVA administration. Maternal diet affected severity of allergic reactions probably via changing in the intestinal microbiota in offspring. Native antigen was observed in breast milk after the perinatal maternal exposure of oral antigen, with resulting sensitization in offspring. However, the sensitization was not enough to induce allergic reactions, and maternal allergen exposure did not affect the severity of allergic reactions after the additional sensitization.
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会议论文
授乳期の抗原摂取が仔の免疫応答に及ぼす影響の解析
哺乳期抗原摄入对子代免疫反应的影响分析
DOI:
--
发表时间:
2014
期刊:
日本農芸化学会2014年度大会
影响因子:
--
作者:
[阿部麻里奈, 渡辺純, 後藤真生, 石川(高野)祐子]
通讯作者:
石川(高野)祐子
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