Relationship between intestinal microbiota and allergy development - Novel target on allergy suppression by food

肠道菌群与过敏发生的关系——食物抑制过敏的新靶点

• 批准号: 23780149
• 负责人: WATANABE Jun
• 金额: $ 3万
• 依托单位: National Agriculture and Food Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23780149/
• 关键词: 食物アレルギー; 腸内細菌; 経母乳感作; 腸内常在細菌叢

The aim of this study was to clarify the relationship between intestinal microbiota and allergy development and the effect of maternal allergen intake during lactating period on immune reactions in offspring. Microbiota was changed in the intestine of DO11.10 mice, when those were sensitized by oral OVA administration. Maternal diet affected severity of allergic reactions probably via changing in the intestinal microbiota in offspring. Native antigen was observed in breast milk after the perinatal maternal exposure of oral antigen, with resulting sensitization in offspring. However, the sensitization was not enough to induce allergic reactions, and maternal allergen exposure did not affect the severity of allergic reactions after the additional sensitization.

本研究旨在阐明肠道菌群与变态反应发生的关系，以及哺乳期母体变应原摄入对子代免疫反应的影响。DO11.10小鼠经口服OVA致敏后，肠道菌群发生变化。母体饮食可能通过改变后代肠道菌群影响过敏反应的严重程度。在围产期母体暴露于口服抗原后，在母乳中观察到天然抗原，导致后代致敏。然而，致敏不足以诱导过敏反应，母体过敏原暴露不影响额外致敏后过敏反应的严重程度。

项目成果

授乳期の抗原摂取が仔の免疫応答に及ぼす影響の解析

哺乳期抗原摄入对子代免疫反应的影响分析

• 发表时间: 2014
• 期刊: 日本農芸化学会2014年度大会
• 作者: 阿部麻里奈;渡辺純;後藤真生;石川(高野)祐子
• 通讯作者: 石川(高野)祐子