Design of immune tolerance inducing peptides and analysis of their allergy-suppressive effects
Design of immune tolerance inducing peptides and analysis of their allergy-suppressive effects
批准号:
18780092
负责人:
WATANABE Jun
金额:
$2.54万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
免疫寛容誘導物質の作製においては、低アレルゲン化小麦粉水溶性画分が免疫寛容誘導活性をもつことを明らかとし、活性本体のペプチドの単離を試みた。腸内細菌とアレルギー発症との関わりを調べ、Candida albicans の定着や幼少期の抗生物質投与による菌叢変化がアレルギーの増悪に関わること、難消化性オリゴ糖の摂取は菌叢変化を介してアレルギー発症に抑制的に作用することを示した。
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Gastrointestinal Candida colonisation promotes sensitization against food antigens by affecting mucosal barrier in mice.
胃肠道念珠菌定植通过影响小鼠粘膜屏障来促进对食物抗原的敏感性。
DOI:
--
发表时间:
2006
期刊:
Gut 55
影响因子:
--
作者:
[Yamaguchi, N., Sugita, R., Miki, A., Takemura, N., Kawabata, J., Watanabe, J., and Sonoyama, K.]
通讯作者:
K.
冬眠中のシリアンハムスターの腸内細菌叢と腸管粘膜バリア
冬眠叙利亚仓鼠的肠道微生物群和肠粘膜屏障
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[園山慶, ら]
通讯作者:
ら
DOI:
10.1016/j.bbrc.2007.06.091
发表时间:
2007-08-31
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ito, Shigeaki, Hamada, Shigeki, Ito, Susumu]
通讯作者:
Ito, Susumu
高発酵性オリゴ糖エピラクトースのミネラル吸収促進作用
高发酵低聚糖表乳糖的矿物质吸收促进作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yamaguchi, N., et al., 渡辺純ら, 西向めぐみら]
通讯作者:
西向めぐみら
メタゲノム的アプローチにより取得した糖質変換酵素様配列の分布
通过宏基因组方法获得的碳水化合物转换酶样序列的分布
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[和崎淳, ら]
通讯作者:
ら
共 28 条
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依托单位:
Molecular structural analysis of membrane proteins incorporated into liposomes or expressed transitionally in the endoplasmic reticulum of transfected COS cells
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依托单位:
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