Studies on degradation of endocrine disruptors by white-rot fungi and molecular breeding of hyper endocrine disruptors-degrading fungi in contaminated soils

研究了高木质素降解白腐菌Phanerochaete sordida YK-624对双酚A（BPA）的降解作用。在木质素分解条件下氧化聚合BPA。另一方面，BPA在非木质素降解条件下羟基化。提示细胞色素P450参与了这种羟基化作用。产生高锰过氧化物酶的转化能够在5天的孵育中消除大约90%的bpa污染土壤。

The degradation of bisphenol A(BPA) was demonstrated with hyper lignin-degrading white-rot fungus Phanerochaete sordida YK-624. BPA was oxidatively polymerized under ligninolytic condition. On the other hand, BPA was hydroxylated under non-ligninolytic condition. It is suggested that cytochrome P450 is involved in this hydroxylation. High manganese peroxidase-producing transformant was able to eliminate BPA-contaminated soil by approximately 90% for 5 day-incubation.