Possible involvement of endoplasmic reticulum protein degradation in Alzheimer's disease

HRD 1作为泛素连接酶促进内质网中未折叠蛋白的降解。在本研究中，我们认为氧化应激可能参与阿尔茨海默病（AD）患者脑中HRD 1蛋白的减少，该蛋白促进淀粉样前体蛋白（APP）的降解。此外，我们评估了HRD 1基因敲除小鼠是否表现出AD的表型。此外，我们还发现了另一种泛素连接酶，它参与APP蛋白的代谢。

HRD1 promotes degradation of unfolded proteins in the endoplasmic reticulum as a ubiquitin ligase. In the present study, we suggest the possible involvement of oxidative stresses in the decrease of HRD1 protein, which promotes degradation of amyloid precursor protein (APP), in the brain of Alzheimer's disease (AD) patient. Furthermore, we evaluated whether HRD1 knockout mice exhibited the phenotypes of AD. In addition, we found another ubiquitin ligase, which is involved in the APP protein metabolism.