The timing to establish the circadian rhythms in development

通过对细胞周期指示物Fucci TG小鼠的观察，发现SCN内的神经元从胚胎到成年逐渐发育。作为起搏器的SCN的背内侧比腹外侧部发育得更快，以重新设定昼夜节律的相位。这一结果与PER1：Luc-Tg小鼠出生后1周开始的昼夜节律自主振荡一致。比较妊娠母鼠与交配雄鼠或其他雄鼠饲养后仔鼠的SCN分化。酒吧SCN的发育往往受到对母鼠不规则刺激的影响。这表明，让母亲处于正常的环境中对于建立酒吧的昼夜节律是重要的。

The neurons in the SCN were developed gradually from fetal to adult by observing cell cycle indicator Fucci Tg mouse. The Dorso Medial in the SCN as pacemaker was developed faster than the Ventro lateral to reset the phase of circadian rhythms. This result was consistent that the circadian rhythms oscillated autonomously since 1week after birth from Per1 : luc Tg mice. The SCN differentiation in pups were compared after pregnant mother mice was kept with mating male or other male. Development in pubs SCN tends to be affected by irregular stimulation to mother mice. It suggests that it is important to keep mother in normal environment for establishing pubs circadian rhythms.