Study of uncharacterized multidrug efflux pumps of Acinetobacter baumannii

多药外排泵在革兰阴性菌的多药耐药机制中起着重要作用。在这项研究中，我检查了多药外排泵与鲍曼不动杆菌的作用，特别是RND家族多药外排泵。明天早上在鲍曼不动杆菌ATCC 19798中，发现了8个推测为RND型多药外排泵的基因簇，其中包括推测为编码膜融合蛋白的A1S 2304、推测为编码RND型多药外排蛋白的A1S 2305和推测为编码外膜蛋白的A1S 2306的基因簇参与了吖啶黄抗性。

Multidrug efflux pumps plays an important role in the multidrug-resistant mechanism of gram-negative bacteria. In this study, I examined the role of multidrug efflux pumps with Acinetobacter baumannii, especially RND family multidrug efflux pumps. In the A. baumannii ATCC19798, eight gene clusters presumed to be RND type multidrug efflux pumps were found. It has been understood that the gene cluster including A1S 2304 presumed to be coding membrane fusion protein, A1S 2305 presumed to be coding RND type multidrug efflux protein and A1S 2306 presumed to be coding outer membrane protein takes part in the acriflavine resistance.