Study of uncharacterized multidrug efflux pumps of Acinetobacter baumannii

多药外排泵在革兰氏阴性菌多药耐药机制中起着重要作用。在这项研究中，我研究了多药外排泵与鲍曼不动杆菌的作用，特别是RND系列多药外排泵。在鲍曼不动杆菌ATCC19798中发现了8个基因簇，推测为RND型多药外排泵。据了解，编码膜融合蛋白的A1S2304、编码RND型多药外排蛋白的A1S2305和编码外膜蛋白的A1S2306等基因簇参与了阿克利黄素的耐药性。

Multidrug efflux pumps plays an important role in the multidrug-resistant mechanism of gram-negative bacteria. In this study, I examined the role of multidrug efflux pumps with Acinetobacter baumannii, especially RND family multidrug efflux pumps. In the A. baumannii ATCC19798, eight gene clusters presumed to be RND type multidrug efflux pumps were found. It has been understood that the gene cluster including A1S 2304 presumed to be coding membrane fusion protein, A1S 2305 presumed to be coding RND type multidrug efflux protein and A1S 2306 presumed to be coding outer membrane protein takes part in the acriflavine resistance.