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Mechanism of Hepatitis C Virus assembly

Mechanism of Hepatitis C Virus assembly
丙型肝炎病毒组装机制
批准号:
21790449
负责人:
HISHIKI Takayuki
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
We found that Hepatitis C virus (HCV) associate with Apolipoprotein E (ApoE) prior to virus release. Moreover, we clarified that ApoE is important factor for HCV infectivity. Infectivity of HCV to cells that were suppressed endogenous LDLR as well as SR-BI was severally reduced. Furthermore, suppression of both the receptors didn't alter the infectivity to cells that were suppressed either one of the receptors. These results suggest that the infectivity of HCV required both LDLR and SR-BI.
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会议论文
C型肝炎ウイルスの増幅機構
丙型肝炎病毒的扩增机制
DOI: --
发表时间: 2009
期刊: 細胞 Vol.41
影响因子: --
作者: [日紫喜隆行, 杉山和夫]
通讯作者: 杉山和夫
DOI: 10.2183/pjab.85.217
发表时间: 2009
期刊: Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子: --
作者: [Ogawa K, Hishiki T, Shimizu Y, Funami K, Sugiyama K, Miyanari Y, Shimotohno K]
通讯作者: Shimotohno K
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [日紫喜隆行, 清水裕子, 宮成悠介, 杉山和夫, 舟見健児, 宇治野真之, 高久洋, 下遠野邦忠]
通讯作者: 下遠野邦忠
Apolipoprotein E isoform affects infectivity of HCV.
载脂蛋白E亚型影响HCV的感染性。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [日紫喜隆行, 清水裕子, 杉山和夫, 舟見健児, 宇治野真之, 高久洋, 下遠野邦忠]
通讯作者: 下遠野邦忠
15
    Mechanistic analysis of viral replication using anti-DENV compound
    海外基金