Studies on the mechanism of tissue-specific modulation of AhR-dependent gene expression

在这项研究中，我们研究了ahr依赖基因表达的组织特异性调节机制，重点关注肝脏和脾脏的转录抑制因子。本研究结果提示，AhRR和hdac的表达以及组蛋白修饰的改变参与了CYP1A1基因表达的组织特异性调节。我们利用ChIP on ChIP对AhR结合区进行全基因组分析，探索了可能以AhR依赖和xre独立的方式进行调控的基因，为了解TCDD组织特异性反应性的机制提供了重要信息。

In this study, we investigated the mechanism of tissue-specific modulation of AhR-dependent gene expression by focusing on the transcriptional repressor in the liver and spleen. The results of this study suggested that expression of AhRR and HDACs and changes of histone modifications were involved in the tissue-specific modulation of CYP1A1 gene expression. We explored the genes which potentially regulated in AhR-dependent and XRE-independent manner in genome wide analysis of AhR binding regions using ChIP on chip, and obtained important information for understanding the mechanism responsible for tissue-specific reactivity of TCDD.