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Identification of the important factor of GM-CSF sensitized dendritic cells that involves with the process of antitumor effect induced by GM-CSF

Identification of the important factor of GM-CSF sensitized dendritic cells that involves with the process of antitumor effect induced by GM-CSF
GM-CSF致敏树突状细胞参与GM-CSF抗肿瘤作用过程的重要因子的鉴定
批准号：
21790773
负责人：
TANAKA Yoshihiro
金额：
$2.58万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790773/
关键词：
GM-CSF樹状細胞センダイウイルスベクター肺癌センダイウィルスベクター

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To identify the mechanism of antitumor effect induced by s.c. administration of GM-CSF gene transduced LLC (LLC/SeV/GM) cells, we conducted cDNA microarray analysis by using GM-CSF-sensitized DCs harvested from tumor-derived lymph nodes. The result showed that the genes involved in type I interferons-producing DCs (plasmacytoid DCs; pDCs), upon activation, were robustly upregulated in GM-DCs compared with its counterpart. Furthermore, the results of both in vivo depletion of pDCs and s.c. co-administration of TLR7 agonist with LLC/SeV/GM cells indicated that pDCs plays central roles on the antitumor effect induced by GM-CSF.
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Comparative microarray analysis implicates the pivotal participation of Type I Interferon related signaling pathway in antitumor effect provoked by in vivo GM-CSF gene transduced lung cancer cells
比较微阵列分析表明 I 型干扰素相关信号通路在体内 GM-CSF 基因转导的肺癌细胞引发的抗肿瘤作用中发挥关键作用
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Megumi Narusawa, Hiroyuki Inoue, Yoshihiro Tanaka, Yosuke Yokota, Chika Sakamoto, Shohei Miyamoto, Tomoko Inoue, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani]
通讯作者： Kenzaburo Tani
Comparable transcriptional profile of murine mature dendritic cells in draining lymph node during tumor rejection by non-transmissible Sendai virus encoding GM-CSF infection
编码 GM-CSF 的非传染性仙台病毒感染肿瘤排斥过程中引流淋巴结中小鼠成熟树突状细胞的可比转录谱
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [成澤慈, 井上博之, 田中芳浩, 横田洋介, 坂本千香, 宮本将平, 井上朋子, 井上誠, 長谷川護, 谷憲三朗]
通讯作者： 谷憲三朗
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Mechanical principle of three-dimensional structure of subcutaneous tissue considering collagen fibers and its application to a high-sensitive and soft tactile sensor
  • 批准号：
    17K20003
  • 项目类别：
    Grant-in-Aid for Challenging Research (Exploratory)
  • 资助金额：
    $4.16万
  • 财政年份：
    2017
  • 负责人：
    TANAKA Yoshihiro
  • 依托单位：
    Nagoya Institute of Technology
Organizing Points of Fundamental Environmental Improvement and Povision of Reasonable Accomodaiton in Japanese Schools
Development of a Tactile Analysis Model based on 3-D Mechanical Structure of Skin Considering Collagen Fibers
  • 批准号：
    26540082
  • 项目类别：
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额：
    $1.91万
  • 财政年份：
    2014
  • 负责人：
    TANAKA Yoshihiro
  • 依托单位：
    Nagoya Institute of Technology
Visibility study on Japanese character with voiced sound marks for children with low vision and development of fonts for low vision children
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