Study of bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell transduced with herpes simplex virus-thymidine kinase gene and ganciclovir

笔者利用转导单纯疱疹病毒胸苷激酶基因的诱导多能干细胞(iPS细胞)和更昔洛韦研究了旁观者效应在恶性胶质瘤治疗中的作用，但遇到了困难。因此，我首先在体内外检测了iPS细胞对恶性胶质瘤和肿瘤相关特异性生长因子的迁移能力。IPS细胞向恶性胶质瘤迁移强度较大。肿瘤相关生长因子参与迁移。我们认为iPS细胞可以成为恶性胶质瘤基因治疗的有效载体。

I studied the bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell (iPS cell) transduced with herpes simplex virus-thymidine kinase gene and ganciclovir, however, it has run into difficulties. So, at first, I examined the migration ability of iPS cells to malignant glioma and tumor-associated specific growth factors in vitro and in vivo. iPS cell show intensive migratory to the malignant gliomas. And tumor-associated growth factors participate in migration. We suggested that iPS cell can become effective vehicles for delivering gene therapies to malignant glioma.