Effects of LECT2 on chondrocyte differentiation

生长板中软骨细胞分化的调控机制尚不完全清楚。在这项研究中，我们分析了LECT2对生长板软骨细胞分化的影响，使用LECT2缺陷小鼠和软骨前细胞细胞系。组织学分析显示，Lect2-KO小鼠生长板结构略有异常。DNA微阵列分析显示，加入LECT2可导致软骨前细胞分化因子的改变。提示LECT2可能参与生长板软骨细胞的分化。

Regulatory mechanisms of chondrocyte differentiation in the growth plate are still not fully understood. In this study, we analyzed effects of LECT2 on growth plate chondrocyte differentiation using Lect2-deficient mice and a prechondrocytic cell line. Histological analysis revealed that Lect2-KO mice have slightly abnormal growth plate structure. DNA microarray analysis shows that addition of LECT2 leads to changes in factors of chondrocyte differentiation in prechondrocytic cell line. These results suggest that LECT2 might participate in the differentiation of growth plate chondrocyte.