The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the neuronal activity and the neurotransmitter in higher micturition centre

我们初步研究了丘脑底核脑深部电刺激（STN-DBS）对排尿反射、纹状体局部场电位和纹状体儿茶酚胺水平的影响。STN-DBS可明显抑制排尿反射，增加排尿功率。频率（约20 Hz），单位为kHz。纹状体中的多巴胺代谢产物（DOPAC和HVA）通过STN-DBS轻微增加，但无统计学意义。其次，我们采用立体定向方法，将6-羟基多巴胺注射到正常大鼠前脑内侧束，建立帕金森病模型大鼠（PD大鼠）。STN-DBS可明显抑制部分PD大鼠排尿反射，并能显著增强PD大鼠的排尿功率。频率为。STN-DBS能显著降低PD模型大鼠纹状体DOPAC的含量，提示STN-DBS对PD模型大鼠和正常大鼠的作用存在差异，这对进一步研究STN-DBS的生理机制具有重要意义。

We initially investigated the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the micturition reflex, local field potential in the STN, and the levels of catecholamine in the striatum, respectively. STN-DBS significantly inhibit the micturition reflex and increase the power in the . frequency (around 20Hz) in STN. Dopamine metabolites (DOPAC and HVA) in the striatum were slightly increased by STN-DBS without statistically significance. In the next, we generated Parkinson's disease model rat (PD rat) by stereotaxically injecting 6-OHDA into the medial forebrain bundle in normal rat. STN-DBS significantly inhibited micturiton reflex in some PD rats and the power in the . frequency in STN. Striatal DOPAC was significantly decreased by STN-DBS.This study showed that the effect of STN-DBS was different between normal and PD model rat, which might be important in examining the physiological mechanisms of STN-DBS.