The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the neuronal activity and the neurotransmitter in higher micturition centre

我们初步观察了丘脑底核深部脑刺激(STN-DBS)对大鼠排尿反射、STN局部场电位和纹状体内儿茶酚胺水平的影响。STN-DBS能明显抑制小鼠排尿反射，增加小鼠排尿功率。STN中的频率(约20赫兹)。STN-DBS组纹状体多巴胺代谢产物(DOPAC和HVA)略有增加，但无统计学意义。在接下来的实验中，我们通过立体定向向正常大鼠的内侧前脑束注射6-OHDA建立了帕金森病模型大鼠(PD大鼠)。STN-DBS能明显抑制部分PD大鼠排尿反射和小鼠排尿能力。STN中的频率。STN-DBS可显著降低纹状体DOPAC。本研究表明，STN-DBS对正常大鼠和帕金森病模型大鼠纹状体DOPAC的影响不同，这可能对探讨STN-DBS的生理机制具有重要意义。

We initially investigated the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the micturition reflex, local field potential in the STN, and the levels of catecholamine in the striatum, respectively. STN-DBS significantly inhibit the micturition reflex and increase the power in the . frequency (around 20Hz) in STN. Dopamine metabolites (DOPAC and HVA) in the striatum were slightly increased by STN-DBS without statistically significance. In the next, we generated Parkinson's disease model rat (PD rat) by stereotaxically injecting 6-OHDA into the medial forebrain bundle in normal rat. STN-DBS significantly inhibited micturiton reflex in some PD rats and the power in the . frequency in STN. Striatal DOPAC was significantly decreased by STN-DBS.This study showed that the effect of STN-DBS was different between normal and PD model rat, which might be important in examining the physiological mechanisms of STN-DBS.