Global analysis of the roles of neurotrophic factors in female reproductions and their clinical applications

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Recent studies revealed that, in addition to sex hormones, networks of diverse growth factors and cytokines have been shown to regulate reproductive functions. In this project, we focused on the roles of neurotrophic factors as novel regulators of female reproductive functions in early follicle growth, preimplantation embryo growth and implantation, and subsequent trophoblasts and placental growth. We demonstrated that BDNF/TrkB signaling had important roles in preimplantation embryo growth and implantation, and subsequent trophoblasts and placental growth.