课题基金 / 基金详情

Association of neck metastasis with tongue cancer stem cells.

Association of neck metastasis with tongue cancer stem cells.
颈部转移与舌癌干细胞的关联。
批准号:
21791603
负责人:
KONDO Satoru
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

KONDO Satoru的其他基金

相似基金

相关文献

中文摘要
翻译
本研究采用边集落法和球体培养法,从舌癌细胞株OSC19中分选出肿瘤干细胞样细胞和非肿瘤干细胞。将CSC和非CSC移植到裸鼠舌体内,并测定其颈部转移率。CSC较非CSC形成更多的舌癌和颈转移瘤。而非CSC可通过增加移植细胞数而形成颈转移。根据这些发现,我们得出结论,CSC和非CSC都具有肿瘤干细胞的表型。通过对舌癌组织的免疫组织化学分析,CD44和ABCG2被确定为CSC转移的候选标记物,但其表达与预后无关。抑制CSC表型可能控制舌癌的颈转移。
英文摘要
Using side population method and spheroid cultivating method, we have sorted cancer stem like cell(CSC) and non-CSC from tongue cancer cell line, OSC19. We transplanted the CSC and non-CSC to tongue of nude mouse and determined frequency of neck metastasis. CSC formed more tumor of tongue and neck metastasis than non-CSC. However, non-CSC could form neck metastasis by increasing of cell the number of cells transplanted. Upon with these findings, we concluded that both CSC and non-CSC have phenotype of cancer stem cells. By analysis with immuno-histochemistry with tongue cancer tissues, CD44 and ABCG2 were determined as candidates of CSC-metastatic marker although the expression does not relate with worse prognosis. Suppression of phenotypes of CSC may control neck metastasis of tongue cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1097/mao.0b013e31820d9654
发表时间: 2011-04
期刊: Otology & Neurotology
影响因子: 2.1
作者: [H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki]
通讯作者: H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki
An extremely rare case of large Delphian node metastasis preceding primary laryngeal cancer
原发性喉癌前发生大德尔菲淋巴结转移的极其罕见病例
DOI: --
发表时间:
期刊: Auris Nasus Larynx (in press)
影响因子: --
作者: [Murono S, Yoshizaki T.]
通讯作者: Yoshizaki T.
DOI: 10.1038/bjc.2011.38
发表时间: 2011-03-29
期刊: BRITISH JOURNAL OF CANCER
影响因子: 8.8
作者: [Horikawa, T., Yoshizaki, T., Kondo, S., Furukawa, M., Kaizaki, Y., Pagano, J. S.]
通讯作者: Pagano, J. S.
Epstein Barr Virus Latent Membrane Protein 1 Initiates Cancer Progenitor Cells in Epithelial Cell Lines
Epstein Barr 病毒潜伏膜蛋白 1 启动上皮细胞系中的癌症祖细胞
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yoshizaki T, Kondo S, et al., 近藤悟]
通讯作者: 近藤悟
共 12 条
    Physiological active substances and fruit affected by light quality
    • 批准号:
      22380020
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.23万
    • 财政年份:
      2010
    • 负责人:
      KONDO Satoru
    • 依托单位:
    Association of single nucleotide polymorphism of MDM2 promoter in nasopharyngeal carcinoma patients
    • 批准号:
      19791198
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.2万
    • 财政年份:
      2007
    • 负责人:
      KONDO Satoru
    • 依托单位:
    Drought tolerance in apple seedlings through abscisic acid (ABA) regulation
    • 批准号:
      19380025
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.4万
    • 财政年份:
      2007
    • 负责人:
      KONDO Satoru
    • 依托单位:
    Study on the free-radical production and stress signal transduction of jasmonates and abscissic acid
    海外基金