A novel osteoimmunological approach to identify the role of bone resident macrophages and the osteonecrosis of the jaw

一种新的骨免疫学方法来识别骨驻留巨噬细胞和颌骨坏死的作用

• 批准号: 21791834
• 负责人: DOMAE Eisuke
• 金额: $ 2.41万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791834/
• 关键词: マクロファージ; 破骨細胞

In this experiment bisphosphonates reduced the adherent strength of osteoclast precursors which are in the process of osteoclast differentiation. Because antibody against adhesion molecules altered osteoclastgenesis, I tried to find the signaling molecules which integrate adhesion molecules and osteoclastgenesis. Syk and Fyn, tyrosine kinases known to be important for osteoclastgenesis, were co-immunoprecipitated with integrins in the process of osteoclastgenesis. These results suggest that outside-in signals from integrins are important for osteoclast-precursor function and differentiation.

在本实验中，双膦酸盐降低了破骨细胞分化过程中的破骨细胞前体的粘附强度。由于抗粘附分子抗体改变破骨细胞的形成，本研究试图寻找整合粘附分子和破骨细胞形成的信号分子。Syk和Fyn是已知对破骨细胞生成重要的酪氨酸激酶，在破骨细胞生成过程中与整合素共免疫沉淀。这些结果表明，由外向内信号整合素是重要的破骨细胞前体功能和分化。

项目成果

ライセニンが破骨細胞分化に及ぼす影響

赖氨酸对破骨细胞分化的影响

• 发表时间: 2010
• 作者: Tamura I;Wato M;Kamada A;Goda S;Yoshikawa Y;Domae E;Tanaka A;Ikeo T;Domae E;堂前英資;堂前英資;堂前英資.
• 通讯作者: 堂前英資.

Enamel Matrix Derivative Protein Stimulated Wound Healing via Phosphoinositide 3-Kinase

• DOI: 10.1902/jop.2009.090127
• 发表时间: 2009-10-01
• 期刊: JOURNAL OF PERIODONTOLOGY
• 影响因子: 4.3
• 作者: Goda, Seiji;Kaneshita, Yuki;Domae, Naochika
• 通讯作者: Domae, Naochika

エムドゲイン刺激が骨芽細胞のMMP-1産生に及ぼす影響

Emdogain 刺激对成骨细胞 MMP-1 产生的影响

• 发表时间: 2009
• 作者: Tamura I;Wato M;Kamada A;Goda S;Yoshikawa Y;Domae E;Tanaka A;Ikeo T;Domae E;堂前英資;堂前英資;堂前英資.;Domae E.;堂前英資;堂前英資
• 通讯作者: 堂前英資

Gene expression of adipocytokine receptors during osteoblastic differentiation

成骨细胞分化过程中脂肪细胞因子受体的基因表达

• 发表时间: 2009
• 期刊: Journal of Oral Tissue Engineering 7
• 作者: Tamura I;Wato M;Kamada A;Goda S;Yoshikawa Y;Domae E;Tanaka A;Ikeo T;Domae E;堂前英資
• 通讯作者: 堂前英資

Kinetics of p120-catenin in a human gingival cancer cell line treated with ZD1839

• DOI: 10.18905/jodu.44.2_169
• 发表时间: 2010-10
• 期刊: Journal of Osaka Dental University
• 作者: I. Tamura;M. Wato;A. Kamada;S. Goda;Yoshihiro Yoshikawa;Eisuke Domae;A. Tanaka;T. Ikeo