Development of reconstruction scaffold for jaw bone made of titanium fiber web with cell induction ability

具有细胞诱导能力的钛纤维网颌骨重建支架的研制

• 批准号: 21791945
• 负责人: HIROTA Makoto
• 金额: $ 2.83万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791945/
• 关键词: チタンファイバー; 顎骨再建; 生体材料; アパタイト; ハイドロキシアパタイトコーティング

The aim of this study was evaluation of the bone regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. A thin HA film was uniformly coated on a TW by the molecular precursor method, without affecting the structure of the TW. Human osteoblasts culture on TW and HA-coated TW (HA/TW) suggested that the HA coated by the molecular precursor method maintained TW architecture and accelerated osteoblast differentiation. Then, TW discs with or without thin HA coating were implanted into rat cranial cortical bone defects, suggesting a thin HA coating enhanced the cortical bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW 3-dimensional scaffold.

本研究的目的是用分子前驱体方法评价涂层羟基磷灰石(HA)薄层的钛纤维网(TW)的骨再生性能。采用分子前驱体方法在薄膜表面均匀涂覆了一层透明质酸薄膜，且不影响薄膜的结构。人成骨细胞在TW和HA包覆TW(HA/TW)上的培养表明，分子前体法包被的HA保持了TW的结构，并促进了成骨细胞的分化。然后，将有或没有薄层HA涂层的TW圆盘植入大鼠颅骨皮质缺损区，提示薄层HA涂层通过保持TW孔隙率和促进TW三维支架的骨传导来促进皮质骨的形成。

项目成果

Molecular precursor method facilitates thin hydroxyapatite coating of titanium fiber web scaffold and enhances bone formation : Experimental study in rat cranial bone defects.

分子前体方法有利于钛纤维网支架的薄羟基磷灰石涂层并增强骨形成：大鼠颅骨缺损的实验研究。

• 发表时间: 2010
• 期刊: International Journal of Oral and Maxillofacial Implnats 25
• 作者: Hirota M;Hayakawa T;Ametani A;他3名
• 通讯作者: 他3名

Use of the molecular precursor method to facilotate thin hydroxyapatite coating titanium fiber web scaffold and enhance bone formation : an experimental study in rat cranial bone defects.

使用分子前体方法促进薄羟基磷灰石涂层钛纤维网支架并增强骨形成：大鼠颅骨缺损的实验研究。

• 发表时间: 2010
• 期刊: International Journal of Oral and Maxillofacial Implants
• 影响因子: 2
• 作者: Hirota M;Hayakawa T;Ametani A;Monden Y;Noishiki Y;Tohnai I
• 通讯作者: Tohnai I

The effect of hydroxyapatite-coated titanium fiber web on human osteoblast functional activity.

羟基磷灰石涂层钛纤维网对人成骨细胞功能活性的影响。

• 发表时间: 2011
• 期刊: International Journal of Oral and Maxillofacial Implants
• 影响因子: 2
• 作者: Hirota M;Hayakawa T;Ametani A;Kuboki Y;Sato M;Tohnai I
• 通讯作者: Tohnai I

Apatite coated titanium fiber web accelerates human osteoblast functional activity.

磷灰石涂层钛纤维网可加速人体成骨细胞功能活动。

• 发表时间: 2011
• 期刊: International Journal of Oral and Maxillofacial Implnats 26
• 作者: Hirota M;Hayakawa T;Ametani A;他3名
• 通讯作者: 他3名