Development of reconstruction scaffold for jaw bone made of titanium fiber web with cell induction ability

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The aim of this study was evaluation of the bone regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. A thin HA film was uniformly coated on a TW by the molecular precursor method, without affecting the structure of the TW. Human osteoblasts culture on TW and HA-coated TW (HA/TW) suggested that the HA coated by the molecular precursor method maintained TW architecture and accelerated osteoblast differentiation. Then, TW discs with or without thin HA coating were implanted into rat cranial cortical bone defects, suggesting a thin HA coating enhanced the cortical bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW 3-dimensional scaffold.