Development of jaw bone reconstruction material made of osteoconductive titanium fiber mesh scaffold.

开发由骨传导性钛纤维网支架制成的颌骨重建材料。

• 批准号: 23792366
• 负责人: HIROTA Makoto
• 金额: $ 2.75万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792366/
• 关键词: 口腔顎顔面再建外科学; 顎骨再建; チタンファイバースキャホールド; チタンファイバー; ティッシュエンジニアリング

The aim of this study was evaluation of the bone regeneration properties of titanium fiber scaffold (TFS) that had been coated with a thin hydroxyapatite (HA) layer. Human osteoblasts culture suggested that the HA coated TFS accelerated osteoblast activity. Reconstructive surgery for rabbit mandibular segmental bone defect using titanium fiber block was performed. The discontinuity of the mandibular bone was completely regenerated by newly formed bone in and on the HA/TFS, suggesting TFS is the materials to reconstruct the jaw bone defects.

本研究的目的是评估涂有薄羟基磷灰石（HA）层的钛纤维支架（TFS）的骨再生特性。人成骨细胞培养表明，HA 包被的 TFS 加速了成骨细胞活性。采用钛纤维块修复兔下颌骨节段性骨缺损。下颌骨的不连续性被HA/TFS内和上新形成的骨完全再生，表明TFS是重建颌骨缺损的材料。

项目成果

Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation

• DOI: 10.1016/j.ijom.2011.12.035
• 发表时间: 2012-10-01
• 期刊: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
• 影响因子: 2.4
• 作者: Hirota, Makoto;Hayakawa, Tohru;Tohnai, Iwai
• 通讯作者: Tohnai, Iwai

Development of mandibular reconstruction device made of titanium fiber scaffold.

钛纤维支架下颌骨重建装置的研制

• 发表时间: 2013
• 作者: Makoto Hirota;Tohru Hayakawa;Takaki Shima;Akihiro Ametani;Iwai Tohnai;Makoto Hirota
• 通讯作者: Makoto Hirota