Development of jaw bone reconstruction material made of osteoconductive titanium fiber mesh scaffold.

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The aim of this study was evaluation of the bone regeneration properties of titanium fiber scaffold (TFS) that had been coated with a thin hydroxyapatite (HA) layer. Human osteoblasts culture suggested that the HA coated TFS accelerated osteoblast activity. Reconstructive surgery for rabbit mandibular segmental bone defect using titanium fiber block was performed. The discontinuity of the mandibular bone was completely regenerated by newly formed bone in and on the HA/TFS, suggesting TFS is the materials to reconstruct the jaw bone defects.