An alternative treatment for osteoporosis with DHNA.

DHNA 治疗骨质疏松症的另一种方法。

• 批准号: 21791995
• 负责人: MURAKAMI Jun
• 金额: $ 2.75万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791995/
• 关键词: 骨粗鬆症; DHNA; 臨床; 薬理学; 遺伝子; 発現制御

The aim of this study is to confirm the antiosteoporotic effect of DHNA in ovariectomized(OVX) mice. This study used female ICR OVX mice and female ICR sham operated mice. OVX mice were randomized into four groups : DHNA group, Vitamine K2(VK) group, Risedronate(Ris) group and control group. Histological and radiographical analysis showed that in the OVX group, the travecular bone was narrow and the bone marrow cavity was wide. On the other hand, these osteoporotic changes were improved in DHNA and Ris group. DHNA had some effects for improving bone mass reduction caused by osteoporosis and may become an alternative medicine for osteoporosis.

本研究的目的是证实DHNA在卵巢切除（OVX）小鼠中的抗骨质疏松作用。本研究使用雌性ICR OVX小鼠和雌性ICR假手术小鼠。将OVX小鼠随机分为4组：DHNA组、维生素K2（VK）组、利塞膦酸钠（Ris）组和对照组。组织学和X线片分析显示，OVX组大鼠横骨狭窄，骨髓腔较宽。而DHNA和Ris组的这些病理改变则有所改善。DHNA对骨质疏松引起的骨量减少有一定的改善作用，有可能成为治疗骨质疏松症的替代药物。

项目成果

In vitro experimental study of the relationship between the apparent diffusion and changes in cellularity and cell morphology

表观扩散与细胞结构和细胞形态变化关系的体外实验研究

• 发表时间: 2009
• 期刊: Oncol Rep
• 影响因子: 4.2
• 作者: Matsumoto Y;Murakami J;et al
• 通讯作者: et al

1, 4-dihydroxy-2-naphthoicacid(DHNA)による骨吸収抑制作用について

关于1, 4-二羟基-2-萘甲酸（DHNA）的骨吸收抑制作用

• 发表时间: 2009
• 作者: 村上純;畝坪輝寿;松崎秀信;柳文修;浅海淳一
• 通讯作者: 浅海淳一

Encyclopedia of DNA research

DNA研究百科全书

• 发表时间: 2012
• 作者: Cox L S

Suppressive effects of 1, 4-dihydroxy-2-naphthoic acid administration on bone resorption

1, 4-二羟基-2-萘酸给药对骨吸收的抑制作用

• 发表时间: 2010
• 期刊: Osteoporos Int
• 作者: Matsubara M;Murakami J;et al
• 通讯作者: et al

Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption.

1,4-二羟基-2-萘酸给药对骨吸收的抑制作用。

• 发表时间: 2009
• 期刊: Osteoporos Int. (in press)
• 作者: Matsubara M;Yamachika E;Tsujigiwa H;Mizukawa N;Ueno T;Murakami J;Ishida N;Kaneda Y;Shirasu N;Takagi S.
• 通讯作者: Takagi S.