Molecular and genetic analysis of osteoclast differentiantion factor and osteoclastgenesis inhibitory factor in osteoporosis and control of inhibition of bone resorption by 1, 4-dihydroxy-2-naphthoic acid(DHNA)
Molecular and genetic analysis of osteoclast differentiantion factor and osteoclastgenesis inhibitory factor in osteoporosis and control of inhibition of bone resorption by 1, 4-dihydroxy-2-naphthoic acid(DHNA)
批准号:
19390516
负责人:
SUGAHARA Toshio
金额:
$12.48万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
免疫抑制剤FK506投与による骨粗懸症に対するプロピオン酸菌の発酵産物(PC)である新規なビフィズス菌増殖因子1, 4-dihydroxy-2-naphthoic acid(DHNA)の効果の検討した。1. DHNAの骨粗鬆症改善効果を証明した。2. この効果はFK506投与により増加したB細胞を減少させ、減少したT細胞を増加させることにより起こると考えられた。3. 骨髄から、マイクロアレイを用いた網羅的解析を行ない、対照群と比較し発現差が認められたのは、骨免疫に関与している2487個の遺伝子であった。
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Hepkakenn ranase contributes to palate fusion by degradind perlecan
Hepkakenn ranase 通过降解基底膜蛋白促进上颚融合
DOI:
--
发表时间:
2008
期刊:
Jounal of Cranio-Maxillofacial Surgery Vol 36, (1)
影响因子:
--
作者:
[A. Hirata, H. Imura, T. Yamada, T. Ueno, E. Yamachika, N. Moritani, T. Matsumura, T. Kagawa, K. Mishima, T. Sugahara]
通讯作者:
T. Sugahara
Application of a novel method to analyze lip motion to cleft lip patients before and after lip repair
应用一种新方法分析唇裂患者唇部修复前后唇部运动
DOI:
--
发表时间:
2009
期刊:
Dentomaxillofac Radiol 38(4)
影响因子:
--
作者:
[Mishima K., Yamade T., Sugii A., Matsumura T., Sugahara T.]
通讯作者:
Sugahara T.
Relationships between nasalance scores and nasopharyngeal shapes in cleft palate patient
腭裂患者鼻音评分与鼻咽形态的关系
DOI:
--
发表时间:
2008
期刊:
J Cranio -Maxillofacial Surgery 36(1)
影响因子:
--
作者:
[Okabayashi S, Takayama K, Kuroda S, Kanai T, Fujii S, Sato M, Kasugai S., Katsuaki Mishima]
通讯作者:
Katsuaki Mishima
TCDD exposed fused palates had various phenomena
TCDD暴露的融合腭有各种现象
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[御手洗誠, 福島忠男, Hideto Imura]
通讯作者:
Hideto Imura
A histological comparison of bone induced from grafted periosteum with bone induced from grafted bone marrow in the rat calvarial defect model
大鼠颅骨缺损模型中骨膜移植骨与骨髓移植骨的组织学比较
DOI:
--
发表时间:
2008
期刊:
Acta Histochmeica 110(3)
影响因子:
--
作者:
[Ueno T, Honda K, Hirata A, Kagawa T, Kanou M, Shirasu N, Sugahara T]
通讯作者:
Sugahara T
共 20 条
Research on metabolic mechanism of palatal processes and cleft palate onset mechanism from genes
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批准号:16K11772
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2016
-
负责人:SUGAHARA Toshio
-
依托单位:
Localization of Perlecan and Heparanase in the Epithelial
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批准号:22592269
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
-
财政年份:2010
-
负责人:SUGAHARA Toshio
-
依托单位:
The study of molecular and gene analysis and bone metabolism-improving effect of propiomibacterium freudenreichii milk whey culture against osteoporosis.
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批准号:17390538
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.05万
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财政年份:2005
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负责人:SUGAHARA Toshio
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依托单位:
Molecule gene analysis of bone absorption in bone reproduction medical care and development of bone absorption restraint medicine
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批准号:15390614
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
-
财政年份:2003
-
负责人:SUGAHARA Toshio
-
依托单位:
A design and manufacture using CAD and CAE system, and its clinical application
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批准号:13470435
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2001
-
负责人:SUGAHARA Toshio
-
依托单位:
Clinical application of our developed artificial temporomandibular joint. 1)study on respiratory function, especially sleep apnea syndrome, 2)study on jaw movement
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批准号:10470433
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.64万
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财政年份:1998
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负责人:SUGAHARA Toshio
-
依托单位:
THE STUDY OF A JAW MOVEMENT BEFORE AND AFTER TOTAL TMJ REPLACEMENT
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批准号:08457548
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.5万
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财政年份:1996
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负责人:SUGAHARA Toshio
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依托单位:
Development of a simulator for educational oral surgery using virtual reality
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批准号:08557115
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.54万
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财政年份:1996
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负责人:SUGAHARA Toshio
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依托单位:
Development of artificial tempolomandibular joint
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批准号:05557090
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$10.82万
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财政年份:1993
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负责人:SUGAHARA Toshio
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依托单位:
Investigation into Pre and Post Operative Functional Changes of Jaw Movement and Oral Cavity Related Muscles of Maxillofacial Deformaties.
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批准号:04454501
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1992
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负责人:SUGAHARA Toshio
-
依托单位:
海外基金