Expression and functional analysis of TPX2 gene in human salivary gland tumors
Expression and functional analysis of TPX2 gene in human salivary gland tumors
批准号:
21791998
负责人:
SHIGEISHI Hideo
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
恶性涎腺癌组织中TPX2和RHAMM基因的表达均高于正常涎腺组织。此外,在细胞周期的有丝分裂阶段,TPX2和RHAMM在有丝分裂纺锤体中也有表达。在细胞周期的M期,rhamm的表达增加。这些结果表明,TPX2和RHAMM在肿瘤细胞的生长中起着重要作用。
英文摘要
The mRNA expression of TPX2 and RHAMM was increased in malignant salivary gland carcinomas compared with that in normal salivary glands. Moreover, TPX2 and RHAMM expression was observed in the mitotic spindle at the mitotic stage of cell cycle. RHAMM expression was increased at the M phase of cell cycle. These results suggest that TPX2 and RHAMM play a significant role in growth of the tumor cells.
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PGE2-induced expression of NR4A2 confers anti-apoptotic capability.
PGE2 诱导的 NR4A2 表达具有抗凋亡能力。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ohta, K., Takechi, M, Minami, M, Shigeishi, H., Hiraoka, M, Nishimura M., Kamata, N., Hideo Shigeishi]
通讯作者:
Hideo Shigeishi
DOI:
10.1111/j.1574-695x.2010.00734.x
发表时间:
2010-11-01
期刊:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
影响因子:
--
作者:
[Ohta, Kouji, Nishi, Hiromi, Kamata, Nobuyuki]
通讯作者:
Kamata, Nobuyuki
DOI:
10.3892/or_00000227
发表时间:
2009-02-01
期刊:
ONCOLOGY REPORTS
影响因子:
4.2
作者:
[Shigeishi, Hideo, Ohta, Kouji, Kamata, Nobuyuki]
通讯作者:
Kamata, Nobuyuki
DOI:
10.3892/or_00000822
发表时间:
2010-07-01
期刊:
ONCOLOGY REPORTS
影响因子:
4.2
作者:
[Ohta, Kouji, Ogawa, Ikuko, Kamata, Nobuyuki]
通讯作者:
Kamata, Nobuyuki
DOI:
10.1177/0022034509338253
发表时间:
2009-06-01
期刊:
JOURNAL OF DENTAL RESEARCH
影响因子:
7.6
作者:
[Shigeishi, H., Yamaguchi, S., Kamata, N.]
通讯作者:
Kamata, N.
共 11 条
Expression analysis of CENP-H gene in human salivary gland carcinomas
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批准号:19791519
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.84万
-
财政年份:2007
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负责人:SHIGEISHI Hideo
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依托单位:
海外基金