Study of Peptidylarginine deiminase type 4(PADI4) as a susceptibility gene of rheumatoid arthritis(RA)

病例-对照关联分析表明PADI 4基因是RA的易感基因之一。为了探讨Padi 4与RA的关系，我们通过缺失Padi 4基因外显子1和外显子2，建立了Padi 4基因敲除（KO）小鼠模型。然而，在CIA的发生率方面没有发现显著差异。Padi 4 KO小鼠显示出比野生型显著更低的抗CII IgG水平。提示PADI 4基因在RA发病中起重要作用。

PADI4 gene was identified as one of susceptibility genes for RA using case-control association study. To investigate relationship between PADI4 and RA, we generate Padi4-knockout(KO) mice by the deleting exon 1 and 2.Significant decrement was found in the severity score of the arthritic mice between wild type and Padi4 KO mice in the development of CIA. However, no significant difference was detected in the incidence of the CIA. Padi4 KO mice showed significantly lower levels of anti-CII IgG than that wild type. These data suggested that the function of PADI4 gene is important for RA.