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A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator

A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator
突触驻留转录共激活因子形成树突棘的新机制
批准号:
21700340
负责人:
YAMAZAKI Hiroyuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
In this study, we analyzed the role of SPIKAR, a novel transcriptional-coactivator, in dendritic spine formation. SPIKAR is localized in not only nucleus but also cytoplasm. We indicated that SPIKAR is involved in early phase of spine formation, especially in filopodia formation. SPIKAR-Knockout mice showed embryonic fatality, suggesting that SPIKAR has pivotal roles in ontogenesis as well as neuronal development.
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DOI: 10.1016/j.biocel.2009.11.019
发表时间: 2010-02
期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
影响因子: 4
作者: [Mercer, Jason C., Qi, Qian, Mottram, Laurie F., Law, Mankit, Bruce, Danny, Iyer, Archana, Morales, J. Luis, Yamazaki, Hiroyuki, Shirao, Tomoaki, Peterson, Blake R., August, Avery]
通讯作者: August, Avery
DOI: 10.1002/cne.22137
发表时间: 2009-11-01
期刊: JOURNAL OF COMPARATIVE NEUROLOGY
影响因子: 2.5
作者: [Aoki, Chiye, Kojima, Nobuhiko, Shirao, Tomoaki]
通讯作者: Shirao, Tomoaki
ドレブリン結合タンパク質 Spikar は細胞質で樹状突起棘形成に関与する
Drebrin 结合蛋白 Spikar 参与细胞质中树突棘的形成
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [奥山輝大, 末廣勇司, 今田はるか, 島田敦子, 田中実, 成瀬清, 武田洋幸, 久保健雄, 竹内秀明, 山崎博幸]
通讯作者: 山崎博幸
DOI: 10.1016/j.neuroscience.2010.06.043
发表时间: 2010-09-15
期刊: NEUROSCIENCE
影响因子: 3.3
作者: [Hanamura, K., Mizui, T., Shirao, T.]
通讯作者: Shirao, T.
13
    Study on various culture investigations for rare marine-derived microorganisms
    • 批准号:
      17KK0173
    • 项目类别:
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • 资助金额:
      $3.08万
    • 财政年份:
      2017
    • 负责人:
      YAMAZAKI Hiroyuki
    • 依托单位:
    Development of induced production method for dormant fungal secondary metabolites with a combination of chemical epigenetics and several culture conditions
    Development of induced production method for dormant fungal secondary biogenesis by modulating new epigenetic targets
    • 批准号:
      25870660
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2013
    • 负责人:
      YAMAZAKI Hiroyuki
    • 依托单位:
    海外基金