A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator
A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator
批准号:
21700340
负责人:
YAMAZAKI Hiroyuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In this study, we analyzed the role of SPIKAR, a novel transcriptional-coactivator, in dendritic spine formation. SPIKAR is localized in not only nucleus but also cytoplasm. We indicated that SPIKAR is involved in early phase of spine formation, especially in filopodia formation. SPIKAR-Knockout mice showed embryonic fatality, suggesting that SPIKAR has pivotal roles in ontogenesis as well as neuronal development.
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DOI:
10.1016/j.biocel.2009.11.019
发表时间:
2010-02
期刊:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
影响因子:
4
作者:
[Mercer, Jason C., Qi, Qian, Mottram, Laurie F., Law, Mankit, Bruce, Danny, Iyer, Archana, Morales, J. Luis, Yamazaki, Hiroyuki, Shirao, Tomoaki, Peterson, Blake R., August, Avery]
通讯作者:
August, Avery
DOI:
10.1002/cne.22137
发表时间:
2009-11-01
期刊:
JOURNAL OF COMPARATIVE NEUROLOGY
影响因子:
2.5
作者:
[Aoki, Chiye, Kojima, Nobuhiko, Shirao, Tomoaki]
通讯作者:
Shirao, Tomoaki
ドレブリン結合タンパク質 Spikar は細胞質で樹状突起棘形成に関与する
Drebrin 结合蛋白 Spikar 参与细胞质中树突棘的形成
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[奥山輝大, 末廣勇司, 今田はるか, 島田敦子, 田中実, 成瀬清, 武田洋幸, 久保健雄, 竹内秀明, 山崎博幸]
通讯作者:
山崎博幸
DOI:
10.1016/j.neuroscience.2010.06.043
发表时间:
2010-09-15
期刊:
NEUROSCIENCE
影响因子:
3.3
作者:
[Hanamura, K., Mizui, T., Shirao, T.]
通讯作者:
Shirao, T.
The role of Spikar in cytoplasm and identification of its functional domain
Spikar在细胞质中的作用及其功能域的鉴定
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[奥山輝大, 末廣勇司, 今田はるか, 島田敦子, 田中実, 成瀬清, 武田洋幸, 久保健雄, 竹内秀明, 山崎博幸]
通讯作者:
山崎博幸
共 13 条
Study on various culture investigations for rare marine-derived microorganisms
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批准号:17KK0173
-
项目类别:Fund for the Promotion of Joint International Research (Fostering Joint International Research)
-
资助金额:$3.08万
-
财政年份:2017
-
负责人:YAMAZAKI Hiroyuki
-
依托单位:
Development of induced production method for dormant fungal secondary metabolites with a combination of chemical epigenetics and several culture conditions
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批准号:16K21310
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
-
财政年份:2016
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负责人:YAMAZAKI Hiroyuki
-
依托单位:
Development of induced production method for dormant fungal secondary biogenesis by modulating new epigenetic targets
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批准号:25870660
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2013
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负责人:YAMAZAKI Hiroyuki
-
依托单位:
海外基金