Functional analysis of NF-Y transcription factor in nervous system

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To investigate physiological function of NF-Y transcription factor in nervous system, we made neuron-specific NF-YA (one of NF-Y components) conditional knockout mice. Although the knockout mice could be born, increase in body weight was severely affected, resulting in neonatal death. We further identified many potential NF-Y target genes involved in gene transcription/translation and protein folding/degradation by ChIP on CHIP analysis using mouse brain. Thus, NF-Y-mediated expression of these genes in neuron may be important for neonatal mouse development.