Investigation of the mechanisms by which antibody to VZV IE62 protein augments mechanical allodynia

VZV IE62 蛋白抗体增强机械异常性疼痛的机制研究

• 批准号: 21700400
• 负责人: TAKASAKI Ichiro
• 金额: $ 2.75万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700400/
• 关键词: 帯状疱疹痛; 帯状疱疹後神経痛; IE62; 帯状疱疹; 脳由来神経栄養因子; アロディニア; Galectin-3; 帯状庖疹; 帯状庖疹後神経痛

Acute herpetic pain and postherpetic neuralgia are intractable neurogenic pain, however the mechanisms of the pain are still unknown. We previously found that immunoreaction to antibody to IE62, one of immediate early protein produced by varicella zoster virus, augment mechanical allodynia in mice with peripheral nerve injury via activation of BDNF activity. In this research, we found that antibody to IE62 augment the acute herpetic pain and increase the transition to postherpetic neuralgia in mice. Using global gene expression analysis, we revealed that spinal galectin-3 is involved in the acute herpetic allodynia. However, we found that galectin-3 is not involved in the anti-IE62 antibody-mediated augmentation of mechanical allodynia.

急性带状疱疹痛和带状疱疹后神经痛是一种难治性神经源性疼痛，但其发生机制尚不清楚。我们以前发现，免疫反应的IE62，即水痘带状疱疹病毒产生的立即早期蛋白之一，增加机械异常性疼痛的周围神经损伤小鼠通过激活BDNF的活性。在这项研究中，我们发现IE62抗体增强了小鼠的急性疱疹疼痛，并增加了向带状疱疹后神经痛的转变。利用全局基因表达分析，我们发现脊髓半乳糖凝集素-3参与急性疱疹性异常性疼痛。然而，我们发现半乳糖凝集素-3不参与抗IE62抗体介导的机械异常性疼痛的增强。

项目成果

Antibody to varicella-zoster virus immediate-early protein IE62 interacts with BDNF and enhances neuropathic allodynia

水痘带状疱疹病毒立即早期蛋白 IE62 抗体与 BDNF 相互作用并增强神经性异常性疼痛

• 发表时间: 2010
• 作者: Takasaki I.;Hama Y.;Yoshida Y.;Daikoku T.;Tsuda M.;Tsumoto T.;Shiraki K.
• 通讯作者: Shiraki K.

Antibody to Varicella-Zoster Virus Immediate-Early Protein 62 Augments Allodynia in Zoster via Brain-Derived Neurotrophic Factor

• DOI: 10.1128/jvi.02061-09
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Hama, Yuka;Shiraki, Kimiyasu;Tsumoto, Tadaharu
• 通讯作者: Tsumoto, Tadaharu

Peripheral-Type Benzodiazepine Receptor Antagonist Is Effective in Relieving Neuropathic Pain in Mice

• DOI: 10.1254/jphs.09028fp
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Kondo, Daisuke;Saegusa, Hironao;Tanabe, Tsutomu
• 通讯作者: Tanabe, Tsutomu

Contribution of spinal galectin-3 to acute herpetic allodynia in mice

• DOI: 10.1016/j.pain.2011.11.022
• 发表时间: 2012-03-01
• 期刊: PAIN
• 影响因子: 7.4
• 作者: Takasaki, Ichiro;Taniguchi, Kana;Kuraishi, Yasushi
• 通讯作者: Kuraishi, Yasushi

帯状疱疹痛と帯状疱疹後神経痛の動物モデルの開発及びアロディニアの発生と抑制作用の機序の解明

带状疱疹疼痛和带状疱疹后神经痛动物模型的开发以及异常性疼痛发生和抑制作用的机制的阐明

• 发表时间: 2010
• 作者: Takasaki I.;Hama Y.;Yoshida Y.;Daikoku T.;Tsuda M.;Tsumoto T.;Shiraki K.;高崎一朗
• 通讯作者: 高崎一朗