Development of new antidepressants from pyrethroid insecticide deltamethrin.

在本研究中，我们研究了二型拟除虫菊酯(DM)在小鼠体内的抗抑郁药样作用。用强迫游泳试验(FST)评价DM的作用，并与I类拟除虫菊酯(PM)进行比较。腹腔注射DM(5 mg/kg和10 mg/kg)可增加大鼠海马区BDNF mRNA的表达。DM可显著缩短大鼠FST的不动时间，对运动活动和运动协调性无明显影响，提示DM具有抗抑郁药样作用。侧脑室注射BDNF受体TrkB的抑制剂K252a可抑制DM的这种作用，提示DM的抗抑郁药样作用是通过BDNF/TrkB信号通路实现的。本研究的结果表明，DM具有抗抑郁药的性质，可能是开发治疗包括抑郁症在内的神经退行性疾病和精神疾病的药物的一个可能来源。

In this study, we investigated the antidepressant-like effect of type II pyrethroid deltamethrin (DM) in mice. The effects of DM were assessed using the forced swimming test (FST) and were compared with those of type I pyrethroid permethrin (PM). Intraperitoneal administration of DM (5 and 10mg/kg) increased the expression of BDNF mRNA in the hippocampus. DM significantly decreased the immobility time in the FST, and did not affect locomotor activity and motor coordination, suggesting that DM has an antidepressant-like effect. This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways. The results of the present study suggest that DM possesses antidepressant-like properties, and may be a possible source for the development of drugs to treat neurodegenerative and psychiatric disorders including depression.