Development of new antidepressants from pyrethroid insecticide deltamethrin.

在这项研究中，我们研究了II型拟除虫菊酯溴氰菊酯（DM）对小鼠的抗抑郁作用。采用强迫游泳试验（FST）评价DM的效果，并与I型拟除虫菊酯氯菊酯（PM）的效果进行比较。腹腔注射DM（5和10mg/kg）可增加海马BDNF mRNA的表达。右美沙芬可显著减少FST的静止时间，但不影响运动活动和运动协调，提示右美沙芬具有抗抑郁样作用。脑室内注射K252a可抑制DM的这种作用，K252a是BDNF受体TrkB的抑制剂，表明DM的抗抑郁样作用是由BDNF/TrkB信号通路介导的。本研究的结果表明，糖尿病具有抗抑郁样特性，可能是开发治疗神经退行性疾病和精神疾病（包括抑郁症）的药物的可能来源。

In this study, we investigated the antidepressant-like effect of type II pyrethroid deltamethrin (DM) in mice. The effects of DM were assessed using the forced swimming test (FST) and were compared with those of type I pyrethroid permethrin (PM). Intraperitoneal administration of DM (5 and 10mg/kg) increased the expression of BDNF mRNA in the hippocampus. DM significantly decreased the immobility time in the FST, and did not affect locomotor activity and motor coordination, suggesting that DM has an antidepressant-like effect. This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways. The results of the present study suggest that DM possesses antidepressant-like properties, and may be a possible source for the development of drugs to treat neurodegenerative and psychiatric disorders including depression.