Analysis of the novel sialylated N-glycan expressed in the mouse brain

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Analyses of glycosyltransferase knockout mice and congenital disorders of glycosylation reveal that N-glycans play important roles in the brain. In this study, we developed a simple method to purify and detect trace amounts of N-glycans. We focused on the analysis of the novel sialylated N-glycan structure, 6-Sialyl-Lewis^c(Galβ1, 3[NeuAcα2, 6] GlcNAc-), found in the mouse brain. We aimed to identify its interacting molecules as well as the protein on which it is beared.