Relation of exercise training, blood sugar level and muscle capillaries network with type 2 diabetes mellitus

有氧运动训练长期以来一直被用作治疗2型糖尿病的方法之一。本文观察了治疗性运动对糖尿病大鼠骨骼肌肌细胞和微循环的影响。有氧运动计划包括在跑步机上跑步2周(0°倾斜，10m/min，60min/d，6d/wk)。与糖尿病大鼠相比，经治疗的糖尿病大鼠的血糖、糖化血红蛋白和活性氧物种(ROS)有所下降，但水平并未完全恢复正常。在非糖尿病大鼠的比目鱼肌中，通常由较高比例的I型MyHC亚型和较低比例的II型MyHC亚型组成。但糖尿病大鼠比目鱼肌中未见II型纤维。训练糖尿病大鼠琥珀酸脱氢酶(SDH)活性显著高于糖尿病大鼠。糖尿病肌肉的毛细血管体积明显减少。在有氧运动的糖尿病肌肉中，毛细血管体积增加到对照水平，并完全恢复正常水平。总之，本研究的结果为运动训练在减少与糖尿病相关的一些肌肉循环并发症方面的有效性提供了证据。

The aerobic exercise training has long been utilized as one of therapy in the type 2 diabetes mellitus. The effects of a therapeutic exercise on the myocyte and the microcirculation of skeletal muscle in diabetic rats were investigated. The aerobic exercise program consisted of 2 weeks running on a treadmill (0°incline, 10m/min, 60min/day, 6day/wk). Treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. Usually, in the soleus muscles of the non-diabetic rats were composed by higher percentage of type I MyHC isoform and lower percentage of type II MyHC isoform. But there were no type II fibers in the soleus muscles of the diabetic rats. The succinate dehydrogenase (SDH) activity in training diabetic rat was significantly higher than that in diabetic rat. The capillary volume in diabetic muscle was significantly less. In the aerobic exercised diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.