Relation of exercise training, blood sugar level and muscle capillaries network with type 2 diabetes mellitus

运动训练、血糖水平和毛细血管网络与2型糖尿病的关系

• 批准号: 21700559
• 负责人: MURAKAMI Shinichiro
• 金额: $ 2.66万
• 依托单位: Himeji Dokkyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700559/
• 关键词: 糖尿病; 運動療法; 血糖値; 微小循環; 筋毛細血管; HbAlc; ミオシン重鎖; 血管内皮細胞増殖因子; 糖化ヘモグロビン; コハク酸脱水素酵素

The aerobic exercise training has long been utilized as one of therapy in the type 2 diabetes mellitus. The effects of a therapeutic exercise on the myocyte and the microcirculation of skeletal muscle in diabetic rats were investigated. The aerobic exercise program consisted of 2 weeks running on a treadmill (0°incline, 10m/min, 60min/day, 6day/wk). Treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. Usually, in the soleus muscles of the non-diabetic rats were composed by higher percentage of type I MyHC isoform and lower percentage of type II MyHC isoform. But there were no type II fibers in the soleus muscles of the diabetic rats. The succinate dehydrogenase (SDH) activity in training diabetic rat was significantly higher than that in diabetic rat. The capillary volume in diabetic muscle was significantly less. In the aerobic exercised diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.

有氧运动长期以来一直被用作2型糖尿病的治疗方法之一。观察了运动疗法对糖尿病大鼠骨骼肌微循环和心肌细胞的影响。有氧运动包括2周的跑台运动（0°坡度，10 m/min，60 min/d，6d/wk）。与糖尿病大鼠相比，经治疗的糖尿病大鼠的血糖、糖化血红蛋白和活性氧（ROS）水平降低，但未完全恢复正常。通常，在非糖尿病大鼠的比目鱼肌中，由较高百分比的I型MyHC亚型和较低百分比的II型MyHC亚型组成。而糖尿病大鼠比目鱼肌中无II型纤维。训练糖尿病大鼠琥珀酸脱氢酶（SDH）活性明显高于糖尿病大鼠。糖尿病肌肉毛细血管容积明显减少，有氧运动后毛细血管容积增加，接近对照组水平，并完全恢复正常。总之，本研究的结果为运动训练在减少与糖尿病相关的一些肌肉循环并发症方面的有效性提供了证据。

项目成果

非肥満性II型糖尿病の筋微小血管障害に対する持久運動の予防的効果

耐力运动对非肥胖 II 型糖尿病肌肉微血管病变的预防作用。

• 发表时间: 2011
• 作者: 廣瀬秀;尾山裕介;吉田彩;村山敏夫;藤野英己，村上慎一郎，近藤浩代，藤田直人，永友文子，武田功，石原昭彦
• 通讯作者: 藤野英己，村上慎一郎，近藤浩代，藤田直人，永友文子，武田功，石原昭彦

Effects of exercise preconditioning on capillary in soleus muscle of type 2 diabetic rats

运动预处理对2型糖尿病大鼠比目鱼肌毛细血管的影响

• 发表时间: 2011
• 作者: Murakami S;Morifuji T;Kondo H;Takeda I;Fujita N;Fujino H
• 通讯作者: Fujino H

Threedimensional visualization of capillary and exercise-induced expression of angiogenic growth factors in skeletal muscle of non-insulin-dependent diabetes.

非胰岛素依赖型糖尿病骨骼肌中毛细血管和运动诱导的血管生成生长因子表达的三维可视化。

• 发表时间: 2010
• 作者: Fujino H;Kondo H;Murakami S;Fujita N;Nagatomo F;Ishihara A.
• 通讯作者: Ishihara A.

Exercise preconditioning attenuates oxidative stress and hyperglycemia in spontaneously diabetic torii rat.

运动预处理可减轻自发性糖尿病 Torii 大鼠的氧化应激和高血糖。

• 发表时间: 2010
• 作者: Kondo H;Fujino H;Murakami S;Nagatomo F;Takeda I;Ishihara A.
• 通讯作者: Ishihara A.

The combined effect of electrical stimulation and resistance isometric contraction on muscle atrophy in rat tibialis anterior muscle.

• DOI: 10.17305/bjbms.2011.2584
• 发表时间: 2011-05
• 期刊: Bosnian journal of basic medical sciences
• 影响因子: 3.4
• 作者: N. Fujita;S. Murakami;Takamitsu Arakawa;A. Miki;H. Fujino