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Effect of exercise to capillary degradation and sarcopenia by aging

Effect of exercise to capillary degradation and sarcopenia by aging
运动对衰老引起的毛细血管退化和肌肉减少症的影响
批准号:
23650340
负责人:
MURAKAMI Shinichiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
翻译
有氧运动训练已成为肌肉老化的治疗手段之一。观察了长期治疗性运动对老年大鼠骨骼肌细胞和微循环的影响。与老年大鼠EDL肌肉相比,治疗老年大鼠有较高的百分比I型肌纤维。训练老年大鼠琥珀酸脱氢酶活性显著高于老年大鼠。有氧运动后,老年大鼠肌肉中PGC-1α、VEGF和FLK-1表达增加。总之,本研究的结果为长期运动训练在减少与毛细血管退化和衰老引起的肌肉减少症相关的一些肌肉循环并发症方面的有效性提供了证据。
英文摘要
The aerobic exercise training has been utilized as one of therapy in the aging muscle. The effects of a long term therapeutic exercise on the myocyte and the microcirculation of skeletal muscle in elderly rats were investigated. Compared with elderly rat EDL muscles, treated elderly rats had higher percentage type I MyHC fibers. The succinate dehydrogenase activity in training elderly rat was significantly higher than that in elderly rat. The capillary volume in elderly rat muscle was significantly less. In the aerobic exercised elderly rat muscles, PGC-1α, VEGF and FLK-1 were increased. In summary, the results of the present study provide evidence for the effectiveness of long term exercise training in reducing some of the muscle circulatory complications associated with capillary degradation and sarcopenia by aging.
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会议论文
II型糖尿病モデルラットの足底筋浅層及び深層筋線維周囲の毛細血管退行に対する運動の予防効果
运动对II型糖尿病模型大鼠足底浅层和深层肌纤维周围毛细血管消退的预防作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [吉田彩, 尾山裕介, 村山敏夫, 藤口理恵子, 淡路千鶴, 椎名祥子,森藤武,村上慎一郎,近藤浩代,藤田直人,藤野英己]
通讯作者: 椎名祥子,森藤武,村上慎一郎,近藤浩代,藤田直人,藤野英己
有酸素運動が2型糖尿病に起因する骨格筋内毛細血管数の減少を予防するメカニズムの検討
研究有氧运动预防 2 型糖尿病引起的骨骼肌毛细血管数量减少的机制。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [笠原央晶, 岩城護, 松村健太, 森藤武,村上慎一郎,椎名祥子,藤田直人,近藤浩代,藤野英己]
通讯作者: 森藤武,村上慎一郎,椎名祥子,藤田直人,近藤浩代,藤野英己
DOI: 10.1155/2011/401493
发表时间: 2011
期刊: Journal of biomedicine & biotechnology
影响因子: --
作者: [Fujita N, Murakami S, Fujino H]
通讯作者: Fujino H
Exercise training prevents the microangiopathy of skeletal muscle in non-obese goto-kakizaki rats.
运动训练可预防非肥胖 goto-kakizaki 大鼠骨骼肌的微血管病。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Fujino H, Kondo H, Murakami S, Nagatomo F, Fujita N, Ishihara A]
通讯作者: Ishihara A
53
    Relation of exercise training, blood sugar level and muscle capillaries network with type 2 diabetes mellitus
    • 批准号:
      21700559
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2009
    • 负责人:
      MURAKAMI Shinichiro
    • 依托单位:
    Research on Juristic-Institutional Transformations in Transition to the "Seconde Republic" in Italy
    • 批准号:
      15530092
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      2003
    • 负责人:
      MURAKAMI Shinichiro
    • 依托单位:
    Research on the Post-Neo-Conservatism of EU Countries in the 21st Century
    • 批准号:
      13620099
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      2001
    • 负责人:
      MURAKAMI Shinichiro
    • 依托单位:
    The Organaizational Transformation of Political Parties under the EU integration
    • 批准号:
      11620086
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      1999
    • 负责人:
      MURAKAMI Shinichiro
    • 依托单位:
    海外基金