Effect of exercise to capillary degradation and sarcopenia by aging

运动对衰老引起的毛细血管退化和肌肉减少症的影响

• 批准号: 23650340
• 负责人: MURAKAMI Shinichiro
• 金额: $ 2.33万
• 依托单位: Himeji Dokkyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650340/
• 关键词: 筋毛細血管; サルコペニア; 血管増殖因子; 加齢性筋減弱症; VEGF; PGC-1α; FLK-1; SDH; 筋横断面積; 筋線維; ミトコンドリア活性; ミオシン

The aerobic exercise training has been utilized as one of therapy in the aging muscle. The effects of a long term therapeutic exercise on the myocyte and the microcirculation of skeletal muscle in elderly rats were investigated. Compared with elderly rat EDL muscles, treated elderly rats had higher percentage type I MyHC fibers. The succinate dehydrogenase activity in training elderly rat was significantly higher than that in elderly rat. The capillary volume in elderly rat muscle was significantly less. In the aerobic exercised elderly rat muscles, PGC-1α, VEGF and FLK-1 were increased. In summary, the results of the present study provide evidence for the effectiveness of long term exercise training in reducing some of the muscle circulatory complications associated with capillary degradation and sarcopenia by aging.

有氧运动训练已被用作治疗衰老肌肉的方法之一。观察了长期治疗性运动对老年大鼠骨骼肌肌细胞和微循环的影响。与老年大鼠EDL肌相比，用药老年大鼠的I型MyHC纤维比例更高。运动老年大鼠琥珀酸脱氢酶活性显著高于老年大鼠。老年大鼠肌肉毛细血管体积明显减少。在有氧运动的老年大鼠肌肉中，前列腺素C-1α、血管内皮生长因子和Flk-1的表达增加。综上所述，本研究的结果为长期运动训练在减少某些肌肉循环并发症方面的有效性提供了证据，这些并发症与毛细血管退化和衰老导致的骨骼减少有关。

项目成果

II型糖尿病モデルラットの足底筋浅層及び深層筋線維周囲の毛細血管退行に対する運動の予防効果

运动对II型糖尿病模型大鼠足底浅层和深层肌纤维周围毛细血管消退的预防作用

• 发表时间: 2011
• 作者: 吉田彩;尾山裕介;村山敏夫;藤口理恵子;淡路千鶴;椎名祥子，森藤武，村上慎一郎，近藤浩代，藤田直人，藤野英己
• 通讯作者: 椎名祥子，森藤武，村上慎一郎，近藤浩代，藤田直人，藤野英己

The combined effect of electrical stimulation and high-load isometric contraction on protein degradation pathways in muscle atrophy induced by hindlimb unloading.

• DOI: 10.1155/2011/401493
• 发表时间: 2011
• 期刊: Journal of biomedicine & biotechnology
• 作者: Fujita N;Murakami S;Fujino H
• 通讯作者: Fujino H

Exercise training prevents the microangiopathy of skeletal muscle in non-obese goto-kakizaki rats.

运动训练可预防非肥胖 goto-kakizaki 大鼠骨骼肌的微血管病。

• 发表时间: 2011
• 作者: Fujino H;Kondo H;Murakami S;Nagatomo F;Fujita N; Ishihara A
• 通讯作者: Ishihara A

有酸素運動が2型糖尿病に起因する骨格筋内毛細血管数の減少を予防するメカニズムの検討

研究有氧运动预防 2 型糖尿病引起的骨骼肌毛细血管数量减少的机制。

• 发表时间: 2012
• 作者: 笠原央晶;岩城護;松村健太;森藤武,村上慎一郎,椎名祥子,藤田直人,近藤浩代,藤野英己
• 通讯作者: 森藤武,村上慎一郎,椎名祥子,藤田直人,近藤浩代,藤野英己

Effect Of Aerobic Training On Three-dimensional Capillary Architecture In Soleus Muscle

有氧训练对比目鱼肌三维毛细血管结构的影响

• 发表时间: 2012
• 作者: Murakami S;Fujita N;Morifuji T;Kondo H;Fujino H
• 通讯作者: Fujino H