Identification of the genetic factor against influenza virus infection in the chicken MHC region.

鸡MHC （MHC- b）是研究兴趣之一，因为在特定的MHC- b单倍型中发现了与禽流感病毒感染的强烈关联。由于缺乏MHC-B单倍型的序列数据，系统地解决MHC-B区域内哪些基因有助于明确定义的MHC-B相关疾病反应的努力受到阻碍。为了确定MHC-B区抗流感病毒感染的遗传因子，我们确定了横跨220kb区域的2个MHC-B单倍型的完整基因组序列，包括从KIFC1到C4的34个基因位点。

The chicken MHC (MHC-B) is one of the research interests because of the strong associations with avian influenza virus infection identified in particular MHC-B haplotypes. Because sequence data of MHC-B haplotypes have been lacking, efforts to systematically resolve which genes within the MHC-B region contribute to well-defined MHC-B-associated disease responses was hampering. To indetify the genetic factor against influenza virus infection in the MHC-B region, we determined the complete genomic sequence of 2 MHC-B haplotypes across a region of 220kb encompassing 34 gene loci ranging from KIFC1 to C4.