Molecular mechanisms of spinal neuro-glial interaction involving neuropathic pain

为了探讨神经性疼痛的新机制，特别是脊髓胶质细胞与神经元之间的相互作用，我们利用大鼠神经性疼痛模型，探讨了伤害感受通路中几种分子的表达及其作用。因此，我们对背根神经节神经元、脊髓背角神经元和脊髓胶质细胞中的ATP受体和脂质介质有了一些新的发现和假设。这些研究结果发表在国际高水平期刊上。

In order to examine the novel mechanism of neuropathic pain, especially interaction between spinal glial cells and neurons, we have used the rat model of neuropathic pain and explored the expression and the role of several molecules in nociceptive pathway. As a result, we have found several new findings and hypotheses about ATP receptors and lipid mediators in dorsal root ganglion neurons, spinal dorsal horn neurons and spinal glial cells. These results were published in international high-level journals.