The mechanism of neuropatic pain model

神经性疼痛模型的机制

• 批准号: 11694327
• 负责人: NOGUCHI Koichi
• 金额: $ 3.52万
• 依托单位: HYOGO COLLEGE OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11694327/
• 关键词: NEUROPATHIC PAIN; ELECTROPHYSIOLOGY; NERVE INJURY; C-FOS; ATF3; 神経損傷; 遺伝子発現

We reported dorsal column-thalamic pathway involvement on thalamic hyperexcitability following peripheral nerve injury usin electrophysiology and neuropathic pain model. We also reported the activating transcription factor-3 induction by axotomy in sensory and motoneurons as a novel neuronal marker of nerve injury. We also reported the excitability of spinal cord and gracile nucleus neurons in rats with chronically injured sciatic nerve using c-fos expression. We also reported the differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model. We also reported the differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia.

我们采用电生理学和神经病理性疼痛模型，研究了背柱-丘脑通路参与周围神经损伤后丘脑的过度兴奋。我们还报道了在感觉和运动神经元中通过轴突切断诱导转录激活因子-3作为神经损伤的新的神经元标记物。我们还报道了慢性坐骨神经损伤大鼠脊髓和薄束核神经元c-fos表达的兴奋性。我们还报道了脑源性神经营养因子在大鼠神经病理性疼痛模型中对高阈值机械敏感性的不同作用。我们还报道了大鼠感觉神经节中完整和受损神经元的外周神经损伤对P2 X3 mRNA表达的差异调节。

项目成果

Fukuoka T et al: "Differential regulation of alopha and beta -"Mol.Brain Res. 63. 304-315 (1999)

Fukuoka T 等人：“α 和 β 的差异调节 -”Mol.Brain Res。

Fukuoka.T., et.al.: "Differential regulation of alpha- and beta-CGRP mRNAs within oculomotor, trochlear,abducens, and trigeminal motoneurons in response to axotomy."Mol.Brain Res.. 63. 304-315 (1999)

Fukuoka.T. 等人：“动眼神经、滑车、外展神经和三叉神经运动神经元内 α-和 β-CGRP mRNA 的差异调节对轴索切断术的反应。”Mol.Brain Res.. 63. 304-315 (1999

Dai Y et al: "Suppression of neuropeptides' mRNA expression"Life Sci. 66. 19-29 (2000)

戴Y等：“神经肽mRNA表达的抑制”生命科学。

Miki, K. et al.: "Dorsal column-thalamic pathway is involved in thalamic hyperexcitability following peripheral nerve injury : A lesion study in rats with experimental mononeuropathy"Pain. 85. 263-271 (2000)

Miki, K. 等人：“背柱-丘脑通路参与周围神经损伤后丘脑的过度兴奋：实验性单神经病大鼠的损伤研究”疼痛。

Fukuoka, T., Tokunaga, A., Kondo, E., Miki, K., Tachibana, T.and Noguchi, K.: "Differential regulation of alpha- and beta CGRP mRNAs within oculomotor, trochlear, abducens, and trigeminal motoneurons in response to axotomy."Mol.Brain Res.. 63. 304-315 (19

Fukuoka, T.、Tokunaga, A.、Kondo, E.、Miki, K.、Tachibana, T. 和 Noguchi, K.：“动眼神经、滑车、外展神经和三叉神经运动神经元内 α- 和 β CGRP mRNA 的差异调节