Molecular mechanisms of neuropathic pain

为了探讨神经性疼痛的新机制，我们利用大鼠神经性疼痛模型，探讨了几种分子在痛觉通路中的表达及其作用。因此，我们发现一些细胞内信号分子、ATP受体和一些细胞因子在背根神经节神经元、脊髓背角神经元和脊髓胶质细胞中起重要作用。这些研究结果发表在国际高水平期刊上。我们相信这些发现有望为神经性疼痛的新治疗药物的开发提供新的种子。

In order to examine the novel mechanism of neuropathic pain, we have used the rat model of neuropathic pain and explored the expression and the role of several molecules in nociceptive pathway. As a result, we have found that some intracellular signaling molecules, ATP receptors and some cytokines have important roles in dorsal root ganglion neurons, spinal dorsal horn neurons and spinal glial cells. These results were published in international high-level journals. We believe that these findings are expected as novel seeds for development of new therapeutic drug of neuropathic pain.