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Molecular analyses on the replication initiation complex and its novel regulatory factors in E. coli

Molecular analyses on the replication initiation complex and its novel regulatory factors in E. coli
大肠杆菌复制起始复合物及其新型调控因子的分子分析
批准号:
22370064
负责人:
KATAYAMA Tsutomu
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
The initiation of the chromosomal DNA replication requires formation of higher-order nucleoprotein complexes and their functions must be regulated during the cell cycle. In this study, by analyzing higher-order complexes formed by the replication origin DNA and the replication initiator DnaA protein in E. coli as a model cell, we identified subcomplexes important for replication initiation reactions and revealed novel molecular mechanisms. Moreover, by analyzing major factors regulating DnaA functions, we revealed a novel regulatory mechanism for DnaA in addition to novel interaction modes between DnaA and the factors
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Dynamics in DNA unwinding of the DnaA-oriC complex
DnaA-oriC 复合物 DNA 解旋动力学
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ozaki, S. and Katayama, T.]
通讯作者: T.
Architecture and mechanism for DNA unwinding of the ATP-DnaA initiation complex of the E. colichromosomal replication.
大肠杆菌染色体复制的 ATP-DnaA 起始复合物的 DNA 解旋结构和机制。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ozaki, S. and Katayama, T.]
通讯作者: T.
制御的DnaA不活性化機構におけるDnaAドメインIの機能解析
DnaA 结构域 I 在 DnaA 失活调控机制中的功能分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [原田雄二, 他]
通讯作者:
大腸菌染色体の複製開始を制御する新たなゲノム配列DARSの機能
控制大肠杆菌染色体复制起始的新基因组序列 DARS 的功能
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [H.Otera, K.Mihara, 片山勉]
通讯作者: 片山勉
77
    Molecular mechanisms on the replication initiation which leads to loading of the helicase and the regulatory systems for the replication initiation
    • 批准号:
      17H03656
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.15万
    • 财政年份:
      2017
    • 负责人:
      KATAYAMA Tsutomu
    • 依托单位:
    Systematic analysis on the inter-gene regions of the Escherichia coli genome
    • 批准号:
      24657004
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.66万
    • 财政年份:
      2012
    • 负责人:
      KATAYAMA Tsutomu
    • 依托单位:
    High-order Structure-based Molecular Mechanisms in Replicational Initiation Complex Formation, DNA Unwinding, and Dissociation
    • 批准号:
      19370077
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.81万
    • 财政年份:
      2007
    • 负责人:
      KATAYAMA Tsutomu
    • 依托单位:
    Protein Dynamics in Complex Apparatus for the Initiation and Regulation of the Chromosomal Replication
    • 批准号:
      16370081
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.64万
    • 财政年份:
      2004
    • 负责人:
      KATAYAMA Tsutomu
    • 依托单位:
    海外基金