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Cytoprotective effects of bioactive molecules derived from bacteria in the intestinal biofilm

Cytoprotective effects of bioactive molecules derived from bacteria in the intestinal biofilm
肠道生物膜中细菌来源的生物活性分子的细胞保护作用
批准号:
22390148
负责人:
KOHGO Yutaka
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010-04-01 至 2014-03-31

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中文摘要
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英文摘要
The present study identified the alterations in the microflora in the intestinal lumen and biofilms, and between healthy volunteers and IBD patients based on an analysis of human and mouse samples. This study showed that probiotics-derived effectors exhibited protective effects against intestinal injury due to intestinal inflammation. The functions were mediated by the interaction between the probiotic-derived effectors and transporters or adherent molecules. These results will be helpful for the development of a novel treatment for intestinal inflammations using probiotic-derived effectors.
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会议论文
腸管保護剤
肠道保护剂
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: []
通讯作者:
A polyphosphate derived from Lactobacillus brevis improves the intestinal barrier function and injury in acute and chronic experimental colitis.
源自短乳杆菌的多磷酸盐可改善急性和慢性实验性结肠炎的肠道屏障功能和损伤。
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Fujiya M, Konishi H, Ueno N, Inaba Y, Ito T, Moriichi K, Tanabe H, Segawa S, Shigyo T, Kohgo Y.]
通讯作者: Kohgo Y.
Trypsin: Structure, Biosynthesis and Functions
胰蛋白酶:结构、生物合成和功能
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Tanabe H, Fujiya M, Kohgo Y.]
通讯作者: Kohgo Y.
DOI: --
发表时间:
期刊:
影响因子: --
作者: [稲場勇平, 藤谷幹浩, 高後 裕.]
通讯作者: 高後 裕.
33
    Development of a novel treatment for inflammatory bowel disease via the regulation of the bacteria recognition system and effective molecules derived from bacteria
    • 批准号:
      19390194
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.07万
    • 财政年份:
      2007
    • 负责人:
      KOHGO Yutaka
    • 依托单位:
    The role of innate immunity in inflammatory bowel disease
    • 批准号:
      15390223
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.15万
    • 财政年份:
      2003
    • 负责人:
      KOHGO Yutaka
    • 依托单位:
    ISOLATION AND STRUCTURE ANALYSIS OF SOLUBLE TRANSFERIN RECEPTOR FOR INTERNATIONAL ASSAY SYSTEM
    • 批准号:
      11557071
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.97万
    • 财政年份:
      1999
    • 负责人:
      KOHGO Yutaka
    • 依托单位:
    INTRINSIC ANTIMICROBIAL POLYPEPTIDE IN INFLAMMATROY BOWEL DISEASE
    • 批准号:
      11694231
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $5.18万
    • 财政年份:
      1999
    • 负责人:
      KOHGO Yutaka
    • 依托单位:
    海外基金