Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation
Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation
批准号:
22390184
负责人:
TAKEDA Jun
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In order to treat type 2 diabetes, it is important to improve body weight and liver glucose uptake. In the process of screening for secreted proteins which could decrease blood glucose, a 32kDa protein was identified by comparison of gene expression profile between normal and diabetic pancreatic islets. Overexpression of the protein in mice significantly increased liver glucose-uptake and decreased fat accumulation in an insulin-independent manner. The plasma levels of the protein secreted were not associated with blood glucose levels in diabetic patients, but with body mass index in obese patients.
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Association of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic acid concentrations with blood flow arteries in Japanese type 2 diabetic patients with normal ankle-brachial index.
踝臂指数正常的日本 2 型糖尿病患者血浆冯维勒布兰德因子瑞斯托菌素辅助因子活性和 5-羟基吲哚乙酸浓度与血流动脉的关系。
DOI:
--
发表时间:
2012
期刊:
J Diabetes Complications
影响因子:
--
作者:
[Murase H, Suzuki E, Tajima Y, Hayashi K, Nakamura T, Noritake N, Takeda J]
通讯作者:
Takeda J
DOI:
10.3748/wjg.v18.i13.1508
发表时间:
2012-04-07
期刊:
WORLD JOURNAL OF GASTROENTEROLOGY
影响因子:
4.3
作者:
[Hamaguchi, Masahide, Takeda, Noriyuki, Takeda, Jun]
通讯作者:
Takeda, Jun
ステロイド糖尿病にリラグルチド投与が有効であった一例
服用利拉鲁肽治疗类固醇糖尿病有效一例
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[水野正巳, 飯塚勝美, 冨田礼子, 諏訪哲 也, 堀川幸男, 武田 純]
通讯作者:
武田 純
The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes
二甲双胍治疗2型糖尿病药物不良反应危险因素评价
DOI:
--
发表时间:
2012
期刊:
Biol Pharm Bull
影响因子:
2
作者:
[Okayasu S, Kitaichi K, Hori A, Suwa T, Horikawa Y, Yamamoto M, Takeda J, Itoh Y]
通讯作者:
Itoh Y
Effectiveness of the glucagon test in estimating islet function for liraglutide treatment in a lean diabetic patient with impaired insulin response to glucose: a case report.
胰高血糖素测试在评估利拉鲁肽治疗胰岛素对葡萄糖反应受损的瘦糖尿病患者的胰岛功能方面的有效性:病例报告。
DOI:
--
发表时间:
2012
期刊:
Diabetol Int
影响因子:
2.2
作者:
[Iizuka K, Tomita R, Horikawa Y, Takeda J.]
通讯作者:
Takeda J.
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