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Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation

Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation
糖尿病治疗增加肝脏葡萄糖摄取并减少脂肪积累
批准号:
22390184
负责人:
TAKEDA Jun
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
In order to treat type 2 diabetes, it is important to improve body weight and liver glucose uptake. In the process of screening for secreted proteins which could decrease blood glucose, a 32kDa protein was identified by comparison of gene expression profile between normal and diabetic pancreatic islets. Overexpression of the protein in mice significantly increased liver glucose-uptake and decreased fat accumulation in an insulin-independent manner. The plasma levels of the protein secreted were not associated with blood glucose levels in diabetic patients, but with body mass index in obese patients.
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Association of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic acid concentrations with blood flow arteries in Japanese type 2 diabetic patients with normal ankle-brachial index.
踝臂指数正常的日本 2 型糖尿病患者血浆冯维勒布兰德因子瑞斯托菌素辅助因子活性和 5-羟基吲哚乙酸浓度与血流动脉的关系。
DOI: --
发表时间: 2012
期刊: J Diabetes Complications
影响因子: --
作者: [Murase H, Suzuki E, Tajima Y, Hayashi K, Nakamura T, Noritake N, Takeda J]
通讯作者: Takeda J
ステロイド糖尿病にリラグルチド投与が有効であった一例
服用利拉鲁肽治疗类固醇糖尿病有效一例
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [水野正巳, 飯塚勝美, 冨田礼子, 諏訪哲 也, 堀川幸男, 武田 純]
通讯作者: 武田 純
DOI: 10.3748/wjg.v18.i13.1508
发表时间: 2012-04-07
期刊: WORLD JOURNAL OF GASTROENTEROLOGY
影响因子: 4.3
作者: [Hamaguchi, Masahide, Takeda, Noriyuki, Takeda, Jun]
通讯作者: Takeda, Jun
The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes
二甲双胍治疗2型糖尿病药物不良反应危险因素评价
DOI: --
发表时间: 2012
期刊: Biol Pharm Bull
影响因子: 2
作者: [Okayasu S, Kitaichi K, Hori A, Suwa T, Horikawa Y, Yamamoto M, Takeda J, Itoh Y]
通讯作者: Itoh Y
43
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