Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation

糖尿病治疗增加肝脏葡萄糖摄取并减少脂肪积累

• 批准号: 22390184
• 负责人: TAKEDA Jun
• 金额: $ 11.73万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390184/
• 关键词: 液性因子; 転写標的; 肥満; 肝脂質代謝; トランスクリプトーム; 膵島; インスリン分泌; ２型糖尿病; 脂肪細胞; 肝糖取込み; 2型糖尿病; 糖新生

In order to treat type 2 diabetes, it is important to improve body weight and liver glucose uptake. In the process of screening for secreted proteins which could decrease blood glucose, a 32kDa protein was identified by comparison of gene expression profile between normal and diabetic pancreatic islets. Overexpression of the protein in mice significantly increased liver glucose-uptake and decreased fat accumulation in an insulin-independent manner. The plasma levels of the protein secreted were not associated with blood glucose levels in diabetic patients, but with body mass index in obese patients.

为了治疗2型糖尿病，改善体重和肝脏葡萄糖摄取是很重要的。在筛选降血糖分泌蛋白的过程中，通过比较正常胰岛和糖尿病胰岛的基因表达谱，鉴定出一个32 kDa的蛋白。该蛋白在小鼠体内的过度表达显著增加了肝脏对葡萄糖的摄取，并以不依赖于胰岛素的方式减少了脂肪堆积。糖尿病患者血浆中分泌的蛋白质水平与血糖水平无关，但与肥胖患者的体重指数有关。

项目成果

Association of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic acid concentrations with blood flow arteries in Japanese type 2 diabetic patients with normal ankle-brachial index.

踝臂指数正常的日本 2 型糖尿病患者血浆冯维勒布兰德因子瑞斯托菌素辅助因子活性和 5-羟基吲哚乙酸浓度与血流动脉的关系。

• 发表时间: 2012
• 期刊: J Diabetes Complications
• 作者: Murase H;Suzuki E;Tajima Y;Hayashi K;Nakamura T;Noritake N;Takeda J
• 通讯作者: Takeda J

Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

• DOI: 10.3748/wjg.v18.i13.1508
• 发表时间: 2012-04-07
• 期刊: WORLD JOURNAL OF GASTROENTEROLOGY
• 影响因子: 4.3
• 作者: Hamaguchi, Masahide;Takeda, Noriyuki;Takeda, Jun
• 通讯作者: Takeda, Jun

ステロイド糖尿病にリラグルチド投与が有効であった一例

服用利拉鲁肽治疗类固醇糖尿病有效一例

• 发表时间: 2012
• 作者: 水野正巳;飯塚勝美;冨田礼子;諏訪哲 也;堀川幸男;武田 純
• 通讯作者: 武田 純

The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes

二甲双胍治疗2型糖尿病药物不良反应危险因素评价

• 发表时间: 2012
• 期刊: Biol Pharm Bull
• 影响因子: 2
• 作者: Okayasu S;Kitaichi K;Hori A;Suwa T;Horikawa Y;Yamamoto M;Takeda J;Itoh Y
• 通讯作者: Itoh Y

Effectiveness of the glucagon test in estimating islet function for liraglutide treatment in a lean diabetic patient with impaired insulin response to glucose: a case report.

胰高血糖素测试在评估利拉鲁肽治疗胰岛素对葡萄糖反应受损的瘦糖尿病患者的胰岛功能方面的有效性：病例报告。

• 发表时间: 2012
• 期刊: Diabetol Int
• 影响因子: 2.2
• 作者: Iizuka K;Tomita R;Horikawa Y;Takeda J.
• 通讯作者: Takeda J.