Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation
糖尿病治疗增加肝脏葡萄糖摄取并减少脂肪积累
基本信息
- 批准号:22390184
- 负责人:
- 金额:$ 11.73万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to treat type 2 diabetes, it is important to improve body weight and liver glucose uptake. In the process of screening for secreted proteins which could decrease blood glucose, a 32kDa protein was identified by comparison of gene expression profile between normal and diabetic pancreatic islets. Overexpression of the protein in mice significantly increased liver glucose-uptake and decreased fat accumulation in an insulin-independent manner. The plasma levels of the protein secreted were not associated with blood glucose levels in diabetic patients, but with body mass index in obese patients.
为了治疗2型糖尿病,重要的是改善体重和肝脏葡萄糖摄取。在筛选降血糖分泌蛋白的过程中,通过比较正常和糖尿病胰岛的基因表达谱,鉴定了一个32kDa的蛋白。在小鼠中蛋白质的过表达以胰岛素非依赖性方式显著增加肝脏葡萄糖摄取并减少脂肪积累。在糖尿病患者中,分泌的蛋白质的血浆水平与血糖水平无关,但与肥胖患者的体重指数有关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of plasma von Willebrand factor ristocetin cofactor activity and 5-hydroxyindole acetic acid concentrations with blood flow arteries in Japanese type 2 diabetic patients with normal ankle-brachial index.
踝臂指数正常的日本 2 型糖尿病患者血浆冯维勒布兰德因子瑞斯托菌素辅助因子活性和 5-羟基吲哚乙酸浓度与血流动脉的关系。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Murase H;Suzuki E;Tajima Y;Hayashi K;Nakamura T;Noritake N;Takeda J
- 通讯作者:Takeda J
Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome
- DOI:10.3748/wjg.v18.i13.1508
- 发表时间:2012-04-07
- 期刊:
- 影响因子:4.3
- 作者:Hamaguchi, Masahide;Takeda, Noriyuki;Takeda, Jun
- 通讯作者:Takeda, Jun
ステロイド糖尿病にリラグルチド投与が有効であった一例
服用利拉鲁肽治疗类固醇糖尿病有效一例
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:水野正巳;飯塚勝美;冨田礼子;諏訪哲 也;堀川幸男;武田 純
- 通讯作者:武田 純
The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes
二甲双胍治疗2型糖尿病药物不良反应危险因素评价
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:2
- 作者:Okayasu S;Kitaichi K;Hori A;Suwa T;Horikawa Y;Yamamoto M;Takeda J;Itoh Y
- 通讯作者:Itoh Y
Effectiveness of the glucagon test in estimating islet function for liraglutide treatment in a lean diabetic patient with impaired insulin response to glucose: a case report.
胰高血糖素测试在评估利拉鲁肽治疗胰岛素对葡萄糖反应受损的瘦糖尿病患者的胰岛功能方面的有效性:病例报告。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:2.2
- 作者:Iizuka K;Tomita R;Horikawa Y;Takeda J.
- 通讯作者:Takeda J.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
TAKEDA Jun其他文献
Aiming to Develop Human Resource Full of Creativity
以培养富有创造力的人才为目标
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
TAKEDA Jun;NAKAMURA Jun'ichi;MORI Hirotaka - 通讯作者:
MORI Hirotaka
TAKEDA Jun的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('TAKEDA Jun', 18)}}的其他基金
Research on archive sharing of English video teaching materials for flipped classrooms utilizing the scale of national colletes of technology
利用国家高专院校规模翻转课堂英语视频教材档案共享研究
- 批准号:
18K00816 - 财政年份:2018
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Missing link between marine protected area and drug trafficking - Toward the study of "protected area for the crime deterrence".
海洋保护区与贩毒之间缺失的联系——“保护区威慑犯罪”研究。
- 批准号:
17K12863 - 财政年份:2017
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Broadband single-shot spectroscopy: visualization of nonlinear optical responses under extremely driving fields
宽带单次光谱:极端驱动场下非线性光学响应的可视化
- 批准号:
16H04001 - 财政年份:2016
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Electron-Phohon Coupling Dynamics in Monolayers via Surface-Enhanced Raman Scattering
通过表面增强拉曼散射研究单层电子-声耦合动力学
- 批准号:
26610083 - 财政年份:2014
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Comprehensive screening of the differentially expressed genes in various conditions for factors involved in the development of endocrine pancreas.
全面筛选各种条件下差异表达基因,寻找内分泌胰腺发育相关因素。
- 批准号:
25670432 - 财政年份:2013
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Time-Frequency Real-Time Imaging and Quantum Control of Phonon-Polariton Propagations
声子极化子传播的时频实时成像和量子控制
- 批准号:
25600113 - 财政年份:2013
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Broadband single-shot imaging spectroscopy using a micro-step echelon optics
使用微步梯形光学器件的宽带单次成像光谱
- 批准号:
23241034 - 财政年份:2011
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
To develop and put into practice the English-teaching materials that lay emphasis on the characteristics of KOSEN students and their English learning.
开发并实施注重KOSEN学生特点和英语学习的英语教材。
- 批准号:
22320116 - 财政年份:2010
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Broadband Single-Shot Real-Time Imaging of Nonlinear Optical Responses in Low-Dimensional and Strongly-Correlated Electrons
低维和强相关电子非线性光学响应的宽带单次实时成像
- 批准号:
22654034 - 财政年份:2009
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Real-Time Imaging and Optical Control of Ultrafast Transient Processes in Nao- and Bio-Related Materials with Extremely Small Quantities
极少量纳米和生物相关材料中超快瞬态过程的实时成像和光学控制
- 批准号:
20241025 - 财政年份:2008
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
相似海外基金
DiGeorge症候群疾患遺伝子産物TBX1の新たな転写標的とその分子機構の解明
阐明迪乔治综合征疾病基因产物TBX1的新转录靶点及其分子机制
- 批准号:
20K09901 - 财政年份:2020
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
β-catenin/Tcf複合体の新規転写標的分子の同定と大腸癌における機能解析
β-catenin/Tcf复合物新型转录靶分子的鉴定及结直肠癌的功能分析
- 批准号:
18659380 - 财政年份:2006
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Exploratory Research
胃がん及び膵がんにおけるWNT信号伝達系の異常による転写標的遺伝子の同定
胃癌和胰腺癌WNT信号转导系统异常转录靶基因的鉴定
- 批准号:
13218146 - 财政年份:2001
- 资助金额:
$ 11.73万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (C)