Functional analysis of Sox11 and Plagl1 in glioma stem cells.

我们研究了Sox11和Plagl1在胶质瘤干细胞（GSC）和神经干细胞（NSC）中的表达及其功能，发现如下结果。(1) Sox11在GSC中的表达不受NeuroD和Neurogenin的调控，两者均诱导Sox11在神经分化中的表达。我们已经确定了在GSC中调控Sox11表达的DNA结构域（200bp）。(2) Plagl1既参与NSC的干性维持，也参与其DNA修复。(3)建立了高效的人GSC制备和维持方法，并检测了其表达谱。

We have examined about the expression of Sox11 and Plagl1 and their functions in glioma stem cells (GSC) and neural stem cells (NSC) and found the following results. (1) Expression of Sox11 in GSC is not regulated by either NeuroD or Neurogenin, both of which induce Sox11 expression in neural differentiation. We have identified the DNA domain (200bp) that regulates Sox11 expression in GSC. (2) Plagl1 is involved in both the maintenance of stemness in NSC and their DNA repair. (3) We have established efficient methods for human GSC preparation and their maintenance and examined their expression profiles.