Interaction between dental pulp stem cells and bone-marrow-derived cells during pulpal regeneration and its clinical implication

牙髓干细胞在牙髓损伤愈合过程中保持成牙细胞的增殖活性和分化能力。此外，供体-宿主相互作用在牙髓的重组中起着至关重要的作用。我们成功地建立了牙本质-牙髓复合体再生评价的体外培养体系。体外器官培养中牙髓-牙本质边界的时间变化与体内实验模型（如牙齿再植/移植）的变化相似。

Dental pulp stem cells retain proliferative activity and differentiation capacity for odontoblasts during pulpal healing following tooth injuries. Furthermore, donor-host interactions play a crucial role in the reorganization of dental pulp. We succeeded to establish the useful in vitro culture system for the evaluation of the dentin-pulp complex regeneration. These chronological changes in the pulp-dentin border in the in vitro organ culture were similar to the changes in the in vivo experimental models such as tooth replantation/transplantation.