Study on the survival strategies for periodontal bacteria in host cells and their role in the pathogenesis of periodontal diseases

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Porphyromonas gingivalisis the major periodontal pathogens. 1) We identified P. gingivalis genes required for survival in the host cells using newly constructed transposon mutagenesis library of P. gingivalis. 2) We found the novel cellular events in host epithelial cells by challenging of P. gingivalis. Akt and its substrates were dephosphorylated by P. gingivalis infection. These results indicated that P. gingivalis-infection may affect cellular functions including apoptosis, glucose metabolism and cell development in host cells by inactivating the PI3K/AKt pathway.