Epidemiological study for identifying risk factors of esophageal adenocarcinoma in north China.

华北地区食管腺癌危险因素流行病学研究.

• 批准号: 22406021
• 负责人: AKAZAWA Kohei
• 金额: $ 6.66万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406021/
• 关键词: 疫学; 国際保健学; 健康管理; 保健医療行政; 地域保健; 集団検診; 医療情報学; 食道扁平上皮癌; 中国疫学調査; リスク因子; 窒素化合物; ロジスティック回帰分析; ホットスポット分析; 食道癌; 腺癌; 条件付きロジスティック回帰分析; マッチングデータ; 環境因子; 喫煙; 飲酒; 扁平上皮癌

Purpose : A matched case-control study to clarify the risk factors of alcohol and tobacco intake on the development of esophageal adenocarcinoma was collected in Hebei Province of China. Multivariate conditional logistic regression analysis indicated that only alcohol consumption was a significant risk factor for esophageal adenocarcinoma. Additional analysis of the combination of amount and duration of alcohol consumption indicated that heavy drinkers (> 30 ml/day) had significantly higher ORs, irrespective of the duration of alcohol consumption. In conclusion, heavy alcohol consumption increases the risk for esophageal adenocarcinoma independent of the duration of such consumption.

目的：收集河北省中国地区烟酒摄入对食管腺癌发病影响因素的配对病例对照研究。多因素条件Logistic回归分析显示，只有饮酒是食管腺癌的显著危险因素。对饮酒量和饮酒时间组合的额外分析表明，无论饮酒时间长短，酗酒者(每天30毫升)的OR值都明显更高。总而言之，大量饮酒会增加患食管腺癌的风险，与饮酒时间无关。

项目成果

Clustering and Geographic Variation of Upper Gastrointestinal Cancers in a High-risk Region of Esophageal Cancer in Northern China

中国北方食管癌高发区上消化道癌的聚集及地理变异

• 发表时间: 2011
• 期刊: Asian Pac J Cancer Prev
• 作者: Zhang N;Wen D;Shan B;Wang S;Zhang L;Wei L;Zou W;Kitsu K;Akazawa K
• 通讯作者: Akazawa K

発癌リスク因子探索のための症例対象研究とその統計学的な性質の解明

基于案例的研究探索癌症危险因素并阐明其统计特性

• 发表时间: 2009
• 作者: 陳君

Heavy alcohol intake is a risk factor for esophageal squamous cell carcinoma among middle-aged Chinese men : a case-control study and simulation

大量饮酒是中国中年男性食管鳞状细胞癌的危险因素：病例对照研究和模拟

• 发表时间: 2013
• 期刊: Molecular and Clinical Oncology
• 影响因子: 1.2
• 作者: Kumagai N;Akazawa K;Wakai T et al
• 通讯作者: Wakai T et al

Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China

• DOI: 10.1620/tjem.226.11
• 发表时间: 2012-01-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Zhang, Nan;Yu, Cao;Wang, Shijie
• 通讯作者: Wang, Shijie

Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer: A case-control study

• DOI: 10.3892/etm.2010.152
• 发表时间: 2010-11-01
• 期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE
• 影响因子: 2.7
• 作者: Chen, Jun;Zhang, Nan;Akazawa, Kohei
• 通讯作者: Akazawa, Kohei