Weak Central Coherence and Executive Function in children with Autism Spectrum Disorder

自闭症谱系障碍儿童的中央一致性和执行功能较弱

基本信息

批准号：
22500244
负责人：
TORII Miyuki
金额：
$ 2.83万
依托单位：
Kobe University (2011-2012)Uekusa Gakuen University (2010)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

1. Weak Central Coherence and Executive Function in children with Autism Spectrum Disorder We investigated both behavioral and neurological aspects of weak central coherence (WCC) in situations similar to those encountered during everyday life. To investigate WCC in situations similar to everyday life, we used large 9 pictures (W80 × H64 cm). Participants were 13 children with ASD and15 typically developing (TD) children. Participantsexplained about each picture. We analyzed verbal responses and also used near-infrared spectroscopy (NIRS) to assess brain activation in the lateral prefrontal cortex (PFC) as the participant explained the picture. ASD children showed lower activation of the right lateral PFC than TD children, while also failing to recognize semantic coherence, suggesting that weak coherence is related to right lateral PFC functioning.2. The Executive Function Strategy Education Program (ESEP) andthe Central Coherence Strategy Education Program (CSEP) for Children with Autism Spectrum Disorder We made the Executive Function Strategy Education Program (ESEP) to train executive function in children with ASD, and the Central Coherence Strategy Education Program (CSEP) to train central coherence in children with ASD. We used the ESEP to train 7 ASD children (ESEP group), and used the CSEP to train 9 ASD children (CSEP group). The effect of the program was measured by DN-CAS (Das-Naglieri Cognitive Assessment System). In ESEP group, the scores of “Simultaneous” and “Planning” were higher than before the training, but the score of “Attention” and “Successive” were not significant. In CSEP group, the score of “Planning” was higher than before the training. In both group, full scoreswere significantly increased.

1。自闭症谱系障碍儿童中的中央连贯性和执行功能较弱，我们研究了与每天生活中遇到的情况相似的情况下，弱中心相干性（WCC）的行为和神经系统方面均研究。为了调查与日常生活类似的情况下的WCC，我们使用了9张大图片（W80×H64 cm）。参与者是13名ASD儿童，15名通常发育（TD）儿童。参与者对每张图片进行了介绍。我们分析了口头反应，还使用近红外光谱法（NIR）来评估参与者解释的图片时，评估横向前额叶皮层（PFC）中的脑激活。 ASD儿童的右侧PFC的激活比TD儿童显示出较低的激活，同时也未能识别语义连贯性，这表明弱连贯性与右侧PFC功能有关。2。执行功能战略教育计划（ESEP）和针对自闭症谱系障碍儿童的中央连贯战略教育计划（CSEP），我们使执行功能战略教育计划（ESEP）培训ASD儿童的执行职能，以及中央连贯战略教育计划（CSEP），以培训患有ASD儿童的中央连贯性。我们使用ESEP培训7个ASD儿童（ESEP组），并使用CSEP培训9个ASD儿童（CSEP组）。该程序的效果是通过DN-CAS（DAS-NAGLIERI认知评估系统）测量的。在Esep集团中，“同时”和“计划”的得分高于培训之前，但是“注意”和“连续”的得分并不显着。在CSEP组中，“计划”的分数高于培训之前。在这两组中，全部得分都显着增加。