Analysis of relationship between age-dependent phenotype change and gene
Analysis of relationship between age-dependent phenotype change and gene
批准号:
22500396
负责人:
TAKAHASHI Eiki
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In this study to examine the relationship between aging and behavioral changes, we used senescence-accelerated mouse (SAM) strain, behavioral tests including motor activity, memory, and alcohol preference tests, and QTL analyses. We have found chromosomal regions involved in age-dependent phenotype changes in the behavioral test. We are trying to identify the causative gene(s) using the database and other mutant strains.
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Behavioral and neurochemical characterization of mice deficient in the N-type calcium channel alpha1B subunit.
N 型钙通道 α1B 亚基缺陷小鼠的行为和神经化学特征。
DOI:
--
发表时间:
2010
期刊:
Behav Brain Res
影响因子:
2.7
作者:
[Vivek Shetty, Corwin Zigler, Theodore F. Robles, David Elashoff, Masaki Yamaguchi, Osamu Nagkagawasai]
通讯作者:
Osamu Nagkagawasai
Neurological Disorders: New Research
神经系统疾病:新研究
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[M. Yamaguchi, Y. Sasaki, Y. Kimura, M. Sasaki, M. Niwayama, 野村大輔,北野哲史,恒成隆,西舘泉,佐藤学, Eiki Takahashi]
通讯作者:
Eiki Takahashi
DOI:
10.1016/j.bbrc.2011.02.071
发表时间:
2011-03-25
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Niimi, Kimie, Nishioka, Chieko, Yamashita, Tadashi]
通讯作者:
Yamashita, Tadashi
Levetiracetam-mediated emotional behavior in heterozygous Rolling Nagoya Cav2.1 channel mutant mice
左乙拉西坦介导的杂合Rolling Nagoya Cav2.1通道突变小鼠的情绪行为
DOI:
10.1016/j.pbb.2010.05.020
发表时间:
2010
期刊:
Pharmacol Biochem Behav
影响因子:
--
作者:
[Takahashi E, Niimi K, Itakura C]
通讯作者:
Itakura C
Interaction between Cav2.1α_1 and CaMKII in Cav2.1α_1 mutant mice, Rolling Nagoya
Cav2.1α_1 突变小鼠中 Cav2.1α_1 与 CaMKII 的相互作用,Rolling Nagoya
DOI:
10.1007/s12031-009-9216-5
发表时间:
2010
期刊:
J Mol Neurosci
影响因子:
3.1
作者:
[Takahashi E, Niimi K, Itakura C]
通讯作者:
Itakura C
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