Multi-scale biomechanical system of blood flow in microcirculation

用计算机模拟了红细胞翻滚和踩坦克运动之间的转换，以确定能再现体外实验中观察到的运动转换的细胞膜弹性常数和自然状态的参数集。对于两支血管模型和基于二维模拟的基于图像的毛细血管网络模型，阐明了依赖于红细胞之间机械相互作用的表观血流特性。通过这些研究，为微循环系统中从红细胞到表观流动行为的多尺度血流行为的机械模拟提供了定量的数据。

A computer simulation of transition between tumbling andtank-treading motions of a red blood cell was carried out to determine a parameter set ofcell membrane's elastic constants and natural states that can reproduce a motiontransition observed inin vitro experiments. Apparent blood flow properties depending onmechanical interaction among red blood cells were clarified for a two-branch blood vesselmodel as well as an image-based capillary network model with two dimensionalsimulations. Through these studies, quantitative data is obtained for mechanical modelingof multiscale blood flow behaviors from a red blood cell to apparent flow behaviors inmicrocirculatory system.