Production of high quality organic micro-crystalsby using templated crystallization as nucleation trigger

使用模板结晶作为成核引发剂生产高质量有机微晶

• 批准号: 22560745
• 负责人: TAKIYAMA Hiroshi
• 金额: $ 2.91万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22560745/
• 关键词: 晶析; 有機微結晶; 泡沫; 鋳型晶析; 核化; 核化トリガー; 鋳型

Fine monomodal crystalline particles are required to manufacture in many fields. In this study, the effect of template at the air/solution interface on the nucleation phenomena was investigated. And the relationship between nucleation timing and the timing in which the template interfaces were given into the supersaturated solution became clear, and nucleation phenomenon of templated crystallization was also investigated. If the timing of nucleation can be controlled by using template effects, monomodal crystalline particles can also be produced. The glycine - water - L-leucine (template compound) system was used. As the results, the nucleation timing of which template interface was given into the supersaturated solution was important for controlling size distribution. The formation of new template interface into the supersaturated solution acted as the nucleation trigger which induced purposeful nucleation. By using this nucleation trigger, monomodal crystalline particles were obtained at the air/solution interface.

在许多领域中需要制造细小的单峰晶体颗粒。在这项研究中，在空气/溶液界面上的成核现象的模板的效果进行了研究。明确了成核时间与模板界面进入过饱和溶液时间的关系，并对模板结晶的成核现象进行了研究。如果成核的时间可以通过使用模板效应来控制，则也可以产生单峰结晶颗粒。使用甘氨酸-水-L-亮氨酸（模板化合物）系统。结果表明，模板界面进入过饱和溶液的成核时间对控制粒径分布有重要意义。在过饱和溶液中形成新的模板界面作为成核触发器，诱导有目的的成核。通过使用该成核触发器，在空气/溶液界面处获得单峰结晶颗粒。

项目成果

気-液界面を晶析場とした有機微結晶粒子群の安定製造

以气液界面为结晶位点稳定生产有机微晶颗粒

• 发表时间: 2010
• 作者: Takiyama;H;Hiroshi TAKIYAMA;片野有規,滝山博志
• 通讯作者: 片野有規,滝山博志

Production of Organic Fine Crystalline Particles by using Liquid-liquid Interface in Emulsion

利用乳液液液界面生产有机细晶颗粒

• 发表时间: 2011
• 作者: Takiyama;H;Hiroshi TAKIYAMA
• 通讯作者: Hiroshi TAKIYAMA

Production of organic micro-crystals by using templated crystallization as nucleation trigger

使用模板结晶作为成核引发剂生产有机微晶

• DOI: 10.1016/j.jcrysgro.2012.11.007
• 发表时间: 2013
• 期刊: Journal of Crystal Growth
• 影响因子: 1.8
• 作者: Yamamoto;H.;H. Takiyama
• 通讯作者: H. Takiyama

Production of Organic Fine-Crystalline Particles by Using the Liquid-Liquid Interface in an Emulsion

利用乳液中的液-液界面生产有机细晶颗粒

• DOI: 10.1002/ceat.201200016
• 发表时间: 2012
• 期刊: Chemical Engineering & Technology
• 影响因子: 2.1
• 作者: Takiyama;H.;K. Ito
• 通讯作者: K. Ito

Production of Organic Fine Crystalline Particles by using Liquid-liquid Inteface in Emulsion

利用乳液液-液界面生产有机细晶粒子

• 发表时间: 2011
• 作者: Takiyama;H
• 通讯作者: H